SynthesisWorld journal of gastroenterology2015
Accuracy of urea breath test in Helicobacter pylori infection: meta-analysis.
Synthesis in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Social determinants of health andFrontiers in public health · 2025Pooled it
- Urea breath test forWorld journal of gastroenterology · 2024Pooled it
- A comparative systematic review and meta-analysis on the diagnostic accuracy of non-invasive tests forFrontiers in medicine · 2023Pooled it
- European guideline on indications, performance and clinical impact ofUnited European gastroenterology journal · 2021Guideline
- Non-invasive diagnostic tests for Helicobacter pylori infection.The Cochrane database of systematic reviews · 2018Pooled it
- Diagnostic accuracy of theWiener klinische Wochenschrift · 2017Pooled it
- Efficacy of 10 days high-dose and double-dose rabeprazole-based concomitant therapy for Helicobacter pylori eradication among Lebanese population: a pilot randomized controlled trial.BMC gastroenterology · 2025Trial
- The prospective multiple-centre randomized controlled clinical study of high-dose amoxicillin-proton pump inhibitor dual therapy forAnnals of medicine · 2022Trial
- Trial
- New fecal test for non-invasiveWorld journal of gastroenterology · 2018Trial
- Ingestible probes for breath-based monitoring of drug-metabolizing activity from the microbiome.Science advances · 2026Article
- Accuracy and Agreement of a 45 mg Versus a 75 mgDiagnostics (Basel, Switzerland) · 2026Article
- Application of artificial intelligence for detection of Helicobacter pylori infection by magnetically controlled capsule endoscopy.Surgical endoscopy · 2026Article
- Correlation between upper gastrointestinal endoscopic findings andThe Pan African medical journal · 2026Article
- Optimal post-gastroscopy timing of the urea [Frontiers in medicine · 2026Article
- Confirmation of Helicobacter pylori eradication using ¹³C urea breath test: addressing the regional post-treatment outcomes.BMC gastroenterology · 2025Article
- Prevalence of Helicobacter pylori Infection and Micronutrient Deficiencies in a Clinically Referred Cohort of Ezidi Refugees in Rural Armidale: Findings from a Retrospective Study.Journal of immigrant and minority health · 2025Article
- Review
- Asia-Pacific Survey on the Management of Helicobacter pylori Infection.Journal of gastroenterology and hepatology · 2025Article
- Prevalence ofWorld journal of gastroenterology · 2025Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo quantitatively summarize and appraise the available evidence of urea breath test (UBT) use to diagnose Helicobacter pylori (H. pylori) infection in patients with dyspepsia and provide pooled diagnostic accuracy measures.
methodsWe searched MEDLINE, EMBASE, Cochrane library and other databases for studies addressing the value of UBT in the diagnosis of H. pylori infection. We included cross-sectional studies that evaluated the diagnostic accuracy of UBT in adult patients with dyspeptic symptoms. Risk of bias was assessed using QUADAS (Quality Assessment of Diagnostic Accuracy Studies)-2 tool. Diagnostic accuracy measures were pooled using the random-effects model. Subgroup analysis was conducted by UBT type (13C vs 14C) and by measurement technique (Infrared spectrometry vs Isotope Ratio Mass Spectrometry).
resultsOut of 1380 studies identified, only 23 met the eligibility criteria. Fourteen studies (61%) evaluated 13C UBT and 9 studies (39%) evaluated 14C UBT. There was significant variation in the type of reference standard tests used across studies.Pooled sensitivity was 0.96 (95%CI: 0.95-0.97) andpooled specificity was 0.93 (95%CI: 0.91-0.94). Likelihood ratio for a positive test was 12 and for a negative test was 0.05 with an area under thecurve of 0.985. Meta-analyses were associated with a significant statistical heterogeneity that remained unexplained after subgroup analysis. The included studies had a moderate risk of bias.
conclusionUBT has high diagnostic accuracy for detecting H. pylori infection in patients with dyspepsia. The reliability of diagnostic meta-analytic estimates however is limited by significant heterogeneity.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.