SynthesisJournal of clinical hypertension (Greenwich, Conn.)2015
Prognostic significance of visit-to-visit systolic blood pressure variability: a meta-analysis of 77,299 patients.
Synthesis in Journal of clinical hypertension (Greenwich, Conn.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Blood pressure variability and cognitive dysfunction: A systematic review and meta-analysis of longitudinal cohort studies.Journal of clinical hypertension (Greenwich, Conn.) · 2021Pooled it
- Prognostic Value of Blood Pressure Variability for Patients With Acute or Subacute Intracerebral Hemorrhage: A Meta-Analysis of Prospective Studies.Frontiers in neurology · 2021Pooled it
- Association Between Blood Pressure Variability and Cerebral Small-Vessel Disease: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2020Pooled it
- Visit-to-visit blood pressure variability and risk of chronic kidney disease: A systematic review and meta-analyses.PloS one · 2020Pooled it
- Blood pressure variability and cardiovascular disease: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2016Pooled it
- China Stroke Primary Prevention Trial: Visit-to-Visit Systolic Blood Pressure Variability Is an Independent Predictor of Primary Stroke in Hypertensive Patients.Journal of the American Heart Association · 2017Trial
- Review
- Redefining cardiometabolic biomarkers in the big data era: toward a personalized medicine-centered reconstruction of risk prediction models.Frontiers in cardiovascular medicine · 2026Article
- Blood pressure variability plays a critical role in determining the prognosis of acute ischemic stroke combined with hypertension.Frontiers in neurology · 2026Article
- Visit-to-Visit Blood Pressure Variability as a Risk Factor for All-Cause Mortality, Cardiovascular Mortality, and Major Adverse Cardiovascular Events Among American Indians: the Strong Heart Study.Preventing chronic disease · 2025Article
- Blood pressure variability associated with in-hospital and 30-day mortality in heart failure patients: a multicenter cohort study.Scientific reports · 2025Article
- Interdialytic home systolic blood pressure variability increases all-cause mortality in hemodialysis patients.Clinical cardiology · 2024Article
- Sex influences blood pressure but not blood pressure variability in response to dietary sodium and potassium in salt-resistant adults.Journal of human hypertension · 2024Article
- Cardiovascular variability, sociodemographics, and biomarkers of disease: the MIDUS study.Frontiers in physiology · 2023Article
- Determinants of visit-to-visit systolic blood pressure variability among Ghanaians with hypertension and diabetes mellitus.Ghana medical journal · 2023Article
- Genetic Determinants of Visit-to-Visit Lipid Variability: Genome-Wide Association Study in Statin-Naïve Korean Population.Frontiers in cardiovascular medicine · 2022Article
- Visit-to-visit blood pressure variability is associated with arterial stiffness in Chinese adults: A prospective analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Association of 1-Year Blood Pressure Variability With Long-term Mortality Among Adults With Coronary Artery Disease: A Post Hoc Analysis of a Randomized Clinical Trial.JAMA network open · 2021Article
- Cost-effectiveness analysis of combining traditional Chinese medicine in the treatment of hypertension: compound Apocynum tablets combined with Nifedipine sustained-release tablets vs Nifedipine sustained-release tablets alone.BMC complementary medicine and therapies · 2020Article
- Systolic blood pressure postural changes variability is associated with greater dementia risk.Neurology · 2020Article
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12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent clinical investigations, visit-to-visit systolic blood pressure (SBP) variability was proven as a predictor of cardiovascular events and all-cause mortality. However, inconsistent results exist in this association. A meta-analysis of 13 prospective studies was conducted to evaluate the prognostic value of visit-to-visit SBP variability by different parameters in 77,299 patients with a mean follow-up of 6.3 years. The pooled age- and mean SBP-adjusted hazard ratios (HRs) for all-cause mortality were 1.03 (95% confidence interval [CI], 1.02-1.04; P<.001) per 1-mm Hg increase in SBP standard deviation (SD) and 1.04 (1.02-1.06, P<.001) per 1% in SBP coefficient of variation, and the corresponding values of cardiovascular mortality were 1.10 (1.02-1.17, P<.001) and 1.01 (0.99-1.03, P=.32), respectively. Moreover, a 1-mm Hg increase in SD was significantly associated with stroke, with an HR of 1.02 (1.01-1.03, P<.001). Visit-to-visit SBP variability, independent of age and mean SBP, is a predictor of cardiovascular and all-cause mortality and stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.