Evidence map›Paper›PMID 25659889›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2016

Intranasal Insulin Improves Age-Related Cognitive Deficits and Reverses Electrophysiological Correlates of Brain Aging.

Shaniya Maimaiti, Katie L Anderson, Chris DeMoll, Lawrence D Brewer, Benjamin A Rauh, John C Gant, Eric M Blalock, Nada M Porter, Olivier Thibault

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Shaniya MaimaitiDepartment of Pharmacology and Nutritional Sciences, University of Kentucky Medical Center, Lexington, Kentucky.
Katie L AndersonDepartment of Pharmacology and Nutritional Sciences, University of Kentucky Medical Center, Lexington, Kentucky.
Chris DeMollDepartment of Pharmacology and Nutritional Sciences, University of Kentucky Medical Center, Lexington, Kentucky.
Lawrence D BrewerDepartment of Pharmacology and Nutritional Sciences, University of Kentucky Medical Center, Lexington, Kentucky.
Benjamin A RauhDepartment of Pharmacology and Nutritional Sciences, University of Kentucky Medical Center, Lexington, Kentucky.
John C GantDepartment of Pharmacology and Nutritional Sciences, University of Kentucky Medical Center, Lexington, Kentucky.
Eric M BlalockDepartment of Pharmacology and Nutritional Sciences, University of Kentucky Medical Center, Lexington, Kentucky.
Nada M PorterDepartment of Pharmacology and Nutritional Sciences, University of Kentucky Medical Center, Lexington, Kentucky.
Olivier ThibaultDepartment of Pharmacology and Nutritional Sciences, University of Kentucky Medical Center, Lexington, Kentucky. othibau@uky.edu.
University of Kentucky · US

Funding

Metabolic syndrome and hippocampal Ca2+ dysregulation in aging-related memory decR01AG033649 · NIA · UNIVERSITY OF KENTUCKY · PI THIBAULT, OLIVIER · 2009 to 2019
$3.4M
NIA NIH HHS R01 AG033649
6 · The paper itself

Abstract

Peripheral insulin resistance is a key component of metabolic syndrome associated with obesity, dyslipidemia, hypertension, and type 2 diabetes. While the impact of insulin resistance is well recognized in the periphery, it is also becoming apparent in the brain. Recent studies suggest that insulin resistance may be a factor in brain aging and Alzheimer's disease (AD) whereby intranasal insulin therapy, which delivers insulin to the brain, improves cognition and memory in AD patients. Here, we tested a clinically relevant delivery method to determine the impact of two forms of insulin, short-acting insulin lispro (Humalog) or long-acting insulin detemir (Levemir), on cognitive functions in aged F344 rats. We also explored insulin effects on the Ca(2+)-dependent hippocampal afterhyperpolarization (AHP), a well-characterized neurophysiological marker of aging which is increased in the aged, memory impaired animal. Low-dose intranasal insulin improved memory recall in aged animals such that their performance was similar to that seen in younger animals. Further, because ex vivo insulin also reduced the AHP, our results suggest that the AHP may be a novel cellular target of insulin in the brain, and improved cognitive performance following intranasal insulin therapy may be the result of insulin actions on the AHP.

Indexed as

AgingBrainCognitionInsulin DetemirInsulin LisproAdministration, IntranasalAnimalsCellular SenescenceCognition DisordersElectrophysiological PhenomenaHypoglycemic AgentsInsulin ResistanceMemoryRatsTreatment OutcomeHypoglycemic AgentsInsulin DetemirInsulin LisproAfterhyperpolarization.CalciumMemoryNeuronal excitabilityType 2 diabetes

Identifiers

PMID25659889
PMCPMC4706100
OpenAlexW2119494733

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.