ArticleBMJ open diabetes research & care2015
Relationship of HbA1c variability, absolute changes in HbA1c, and all-cause mortality in type 2 diabetes: a Danish population-based prospective observational study.
Article in BMJ open diabetes research & care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Glycaemic variation is a predictor of all-cause mortality in the Veteran Affairs Diabetes Trial.Diabetes & vascular disease research · 2019Trial
- Glycemic Variation and Cardiovascular Risk in the Veterans Affairs Diabetes Trial.Diabetes care · 2018Trial
- Association between estimated glucose disposal rate and major adverse cardiovascular events in patients with type 2 diabetes.PloS one · 2025Article
- BMI variability and cardiovascular outcomes within clinical trial and real-world environments in type 2 diabetes: an IMI2 SOPHIA study.Cardiovascular diabetology · 2024Observational
- Prognostic value of longitudinal HbA1c variability in predicting the development of diabetic sensorimotor polyneuropathy among patients with type 2 diabetes mellitus: A prospective cohort observational study.Journal of diabetes investigation · 2024Observational
- Glycated hemoglobin variability and the risk of cardiovascular events in patients with prediabetes and type 2 diabetes mellitus: A post-hoc analysis of a prospective and multicenter study.Journal of diabetes investigation · 2023Observational
- Glycemic control, HbA1c variability, and major cardiovascular adverse outcomes in type 2 diabetes patients with elevated cardiovascular risk: insights from the ACCORD study.Cardiovascular diabetology · 2023Article
- Lipid Profile, Renal Function Tests and Inflammatory Markers in Algerian Type 2 Diabetic Patients.Iranian journal of public health · 2023Article
- HbA1c Variability and Cardiovascular Events in Patients with Prostate Cancer Receiving Androgen Deprivation Therapy.European urology open science · 2023Article
- Association between hemoglobin glycation index and diabetic kidney disease in type 2 diabetes mellitus in China: A cross- sectional inpatient study.Frontiers in endocrinology · 2023Article
- Early and ongoing stable glycaemic control is associated with a reduction in major adverse cardiovascular events in people with type 2 diabetes: A primary care cohort study.Diabetes, obesity & metabolism · 2022Article
- Enterocyte HKDC1 Modulates Intestinal Glucose Absorption in Male Mice Fed a High-fat Diet.Endocrinology · 2022Article
- Heterogeneous treatment effects of intensive glycemic control on major adverse cardiovascular events in the ACCORD and VADT trials: a machine-learning analysis.Cardiovascular diabetology · 2022Article
- Risk stratification of cardiac arrhythmias and sudden cardiac death in type 2 diabetes mellitus patients receiving insulin therapy: A population-based cohort study.Clinical cardiology · 2021Observational
- Mean and visit-to-visit variability of glycated hemoglobin, and the risk of non-alcoholic fatty liver disease.Journal of diabetes investigation · 2021Article
- Glycemic and lipid variability for predicting complications and mortality in diabetes mellitus using machine learning.BMC endocrine disorders · 2021Observational
- Predictions of diabetes complications and mortality using hba1c variability: a 10-year observational cohort study.Acta diabetologica · 2021Observational
- Long-Term Glycemic Variability Is Associated With Arterial Stiffness in Chinese Adults.Frontiers in endocrinology · 2021Article
- Long-term variability of glycemic markers and risk of all-cause mortality in type 2 diabetes: the Look AHEAD study.BMJ open diabetes research & care · 2020Article
- Sociodemographic factors associated with HbA1c variability in type 2 diabetes: a prospective exploratory cohort study.BMC endocrine disorders · 2020Article
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Abstract
objectiveWe assessed the relationship of mortality with glycated hemoglobin (HbA1c) variability and with absolute change in HbA1c.
designA population-based prospective observational study with a median follow-up time of 6 years.
methodsBased on a validated algorithm, 11 205 Danish individuals with type 2 diabetes during 2001-2006 were identified from public data files, with at least three HbA1c measurements: one index measure, one closing measure 22-26 months later, and one measurement in-between. Medium index HbA1c was 7.3%, median age was 63.9 years, and 48% were women. HbA1c variability was defined as the mean absolute residual around the line connecting index value with closing value. Cox proportional hazard models with restricted cubic splines were used, with all-cause mortality as the outcome.
resultsVariability between 0 and 0.5 HbA1c percentage point was not associated with mortality, but for index HbA1c ≤8% (64 mmol/mol), a variability above 0.5 was associated with increased mortality (HR of 1 HbA1c percentage point variability was 1.3 (95% CI 1.1 to 1.5) for index HbA1c 6.6-7.4%). For index HbA1c≤8%, mortality increased when HbA1c declined, but was stable when HbA1c rose. For index HbA1c>8%, change in HbA1c was associated with mortality, with the lowest mortality for greatest decline (HR=0.9 (95% CI 0.80 to 0.98) for a 2-percentage point decrease).
conclusionsFor individuals with an index HbA1c below 8%, both high HbA1c variability and a decline in HbA1c were associated with increased mortality. For individuals with index HbA1c above 8%, change in HbA1c was associated with mortality, whereas variability was not.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.