ArticleInflammation2015
Anti-inflammatory and Antioxidative Activities of Safranal in the Reduction of Renal Dysfunction and Damage that Occur in Diabetic Nephropathy.
Article in Inflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 48 citations in OpenAlex.
- Safranal Ameliorates Renal Damage, Inflammation, and Podocyte Injury in Membranous Nephropathy via SIRT/NF-κB Signalling.Current medical science · 2025Article
- Integrative transcriptome and metabolome analysis reveals candidate genes related to terpene synthesis in Chrysanthemum × morifolium.BMC plant biology · 2025Article
- Saffron, a Potential Bridge between Nutrition and Disease Therapeutics: Global Health Challenges and Therapeutic Opportunities.Plants (Basel, Switzerland) · 2024Review
- Inflammatory corpuscle AIM2 facilitates macrophage foam cell formation by inhibiting cholesterol efflux protein ABCA1.Scientific reports · 2024Article
- Effects ofIranian journal of basic medical sciences · 2024Article
- Pharmacological effects of Safranal: An updated review.Iranian journal of basic medical sciences · 2023Review
- Saffron (Nutrients · 2022Review
- Lycopene attenuates high glucose-mediated apoptosis in MPC5 podocytes by promoting autophagy via the PI3K/AKT signaling pathway.Experimental and therapeutic medicine · 2020Article
- Current Drugs and Potential Future Neuroprotective Compounds for Parkinson's Disease.Current neuropharmacology · 2019Review
- Carbohydrate response element binding protein (ChREBP) modulates the inflammatory response of mesangial cells in response to glucose.Bioscience reports · 2018Article
- Article
- Dexmedetomidine Ameliorates Acute Stress-Induced Kidney Injury by Attenuating Oxidative Stress and Apoptosis through Inhibition of the ROS/JNK Signaling Pathway.Oxidative medicine and cellular longevity · 2018Article
- Metabolic effects ofBiomedical reports · 2017Article
- HMGB1 is activated in type 2 diabetes mellitus patients and in mesangial cells in response to high glucose.International journal of clinical and experimental pathology · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic nephropathy is one of the most important complications of both type 1 and type 2 diabetes. The aim of this study is to investigate the curative and renal damage-reducing effects of safranal on inflammation and oxidative stress in diabetic nephropathy. Experimental type 2 diabetes was created in rats by use of high-fat diet (HFD) and streptozotocin (STZ) in the experimental animals. Safranal was then administered to two of the five experimental groups (type 2 diabetes group (DYB) and HFD groups) for a period of 4 weeks. At the end of the 10-week study, the serum blood urea nitrogen (BUN) and creatinine (CREA) levels, renal tissue oxidative stress parameters (total antioxidant capacity (TAS), total oxidant capacity (TOS), oxidative stress index (OSI), GSH, NO), and cytokine levels (TNF-α, IL-1β, IL-18, IFN-γ) were analyzed. In addition, the effect of safranal on the diabetic nephropathy-induced damage in renal tissue was also analyzed histopathologically. In this study, safranal was found to reduce dysfunction (lowered BUN and CREA levels) and tissue damage (histopathological data) that occur in renal tissue, by means of its both antioxidative and anti-inflammatory activities. In the light of these results, we suggest that safranal contributes to the development of new treatment protocols in the treatment of type 2 diabetes and its complication diabetic nephropathy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.