ArticleMetabolism: clinical and experimental2015
Metabolic syndrome burden in apparently healthy adolescents is adversely associated with cardiac autonomic modulation--Penn State Children Cohort.
Article in Metabolism: clinical and experimental, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Effect of high-intensity childhood games on heart rate variability, saliva leptin concentrations, and body composition in children.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025Trial
- The influence of interval training combined with occlusion and cooling on lipid profile in young healthy people.Frontiers in physiology · 2026Article
- Article
- Article
- Evaluating eight indicators for identifying metabolic syndrome in Chinese and American adolescents.Pediatric research · 2024Article
- Circadian misalignment impacts the association of visceral adiposity with metabolic syndrome in adolescents.Sleep · 2024Article
- Edward O. Bixler, PhD: from the Apollo project and chimpanzees to sleep epidemiology.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Heart rate thresholds for cardiovascular risk and sympathetic activation in the metabolic syndrome.Acta diabetologica · 2022Article
- The impact of social disadvantage on autonomic physiology of latinx adolescents: The role of environmental risks.New directions for child and adolescent development · 2022Article
- Review
- Validation of a continuous measure of cardiometabolic risk among adolescents.Journal of pediatric endocrinology & metabolism : JPEM · 2021Article
- Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association.Circulation · 2021Article
- Anthropometric measurements as a potential non-invasive alternative for the diagnosis of metabolic syndrome in adolescents.Archives of endocrinology and metabolism · 2019Article
- Higher blood pressure and lower cardiac vagal activity in obese young individuals in supine and seated position.Journal of clinical and translational research · 2018Article
- Non-alcoholic fatty liver disease and its associations among adolescents in an urban, Sri Lankan community.BMC gastroenterology · 2017Article
- Galantamine alleviates inflammation and insulin resistance in patients with metabolic syndrome in a randomized trial.JCI insight · 2017Article
- Association of evening smartphone use with cardiac autonomic nervous activity after awakening in adolescents living in high school dormitories.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
- Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association.Circulation · 2017Review
- Association of metabolic syndrome and electrocardiographic markers of subclinical cardiovascular disease.Diabetology & metabolic syndrome · 2017Article
- Antenatal steroid exposure and heart rate variability in adolescents born with very low birth weight.Pediatric research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundReduced cardiac autonomic modulation (CAM) has been associated with metabolic syndrome (MetS) in adults. However, the association between MetS component cluster and CAM has not been examined in adolescents.
methodsWe conducted a cross-sectional analysis using data from the Penn State Child Cohort follow-up examination. CAM was assessed by heart rate variability (HRV) analysis of 39-h RR intervals, including frequency (high frequency, HF; low frequency, LF; and LF/HF ratio) and time (SDNN, standard deviation of all RR intervals; RMSSD, square root of the mean of the sum of the squares of differences between adjacent RR intervals; and HR, heart rate) domain variables. To assess the MetS burden, we used continuous MetS score (cMetS)--sum of the age and sex-adjusted standardized residual (Z-score) of five established MetS components. Linear mixed-effect models were used to analyze the association between cMetS and CAM in the entire population and stratified by gender.
resultsAfter adjusting for age, sex, and race, cMetS was significantly associated with reduced HRV and higher HR. With 1 standard deviation increase in cMetS, there was a significant decrease in HF (-0.10 (SE = 0.02)), LF (-0.07 (SE = 0.01)), SDNN (-1.97 (SE = 0.50)), and RMSSD (-1.70 (SE = 0.72)), and increase in LF/HF (0.08 (SE = 0.02)) and HR (1.40 (SE = 0.26)). All cMetS components, with the exception of high-density lipoprotein (HDL), were associated with significantly decreased HRV and increased HR. High blood pressure (MAP) and triglyceride (TG) levels were also associated with an increase in LF/HF and decrease in RMSSD. An increase in high-density lipoprotein was only associated with higher LF and SDNN. Moreover, cMetS and HRV associations were more pronounced in males than in females. The associations between HRV and. MAP, TG, and HDL were more pronounced in females.
conclusionscMetS score is associated with lower HRV, suggesting an adverse impact on CAM, even in apparently healthy adolescents.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.