Is brain insulin action relevant to the control of plasma glucose in humans?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

8 citing papers in PubMed.

1. Central Regulation of Glucose Production May Be Impaired in Type 2 Diabetes.Diabetes · 2016
   Trial
2. Insulin evokes release of endozepines from astrocytes of the NTS to modulate glucose metabolism in male rats.Molecular metabolism · 2025
   Article
3. Brain insulin signalling in metabolic homeostasis and disease.Nature reviews. Endocrinology · 2021
   Review
4. Importance of the route of insulin delivery to its control of glucose metabolism.American journal of physiology. Endocrinology and metabolism · 2021
   Article
5. Regulation of Postabsorptive and Postprandial Glucose Metabolism by Insulin-Dependent and Insulin-Independent Mechanisms: An Integrative Approach.Nutrients · 2021
   Review
6. Molecular Mechanisms of Hypothalamic Insulin Resistance.International journal of molecular sciences · 2019
   Review
7. Neuronal control of peripheral insulin sensitivity and glucose metabolism.Nature communications · 2017
   Review
8. Impaired insulin action in the human brain: causes and metabolic consequences.Nature reviews. Endocrinology · 2015
   Review

Corrections and comments

• Comment on
  Central nervous insulin administration does not potentiate the acute glucoregulatory impact of concurrent mild hyperinsulinemia.2015
• Comment on
  Intranasal insulin suppresses endogenous glucose production in humans compared with placebo in the presence of similar venous insulin concentrations.2015

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as