Evidence map›Paper›PMID 25747752›Full record

Trial reportAmerican journal of physiology. Heart and circulatory physiology2015

Exercise training prevents the deterioration in the arterial baroreflex control of sympathetic nerve activity in chronic heart failure patients.

Raphaela V Groehs, Edgar Toschi-Dias, Ligia M Antunes-Correa, Patrícia F Trevizan, Maria Urbana P B Rondon, Patrícia Oliveira, Maria J N N Alves, Dirceu R Almeida, Holly R Middlekauff, Carlos E Negrão

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of physiology. Heart and circulatory physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 4 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Raphaela V GroehsHeart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil;
Edgar Toschi-DiasHeart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil;
Ligia M Antunes-CorreaHeart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil;
Patrícia F TrevizanHeart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil;
Maria Urbana P B RondonSchool of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
Patrícia OliveiraHeart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil;
Maria J N N AlvesHeart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil;
Dirceu R AlmeidaDivision of Cardiology, Department of Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil;
Holly R MiddlekauffDepartment of Medicine (Cardiology) and Physiology, Geffen School of Medicine at UCLA, University of California, Los Angeles, California.
Carlos E NegrãoHeart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil; School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil, cndnegrao@incor.usp.br.
Universidade de São Paulo · BRUniversidade Federal de São Paulo · BRUniversity of California, Los Angeles · US

Funding

NHLBI NIH HHS R01-HL084525
6 · The paper itself

Abstract

Arterial baroreflex control of muscle sympathetic nerve activity (ABRMSNA) is impaired in chronic systolic heart failure (CHF). The purpose of the study was to test the hypothesis that exercise training would improve the gain and reduce the time delay of ABRMSNA in CHF patients. Twenty-six CHF patients, New York Heart Association Functional Class II-III, EF ≤ 40%, peak V̇o2 ≤ 20 ml·kg(-1)·min(-1) were divided into two groups: untrained (UT, n = 13, 57 ± 3 years) and exercise trained (ET, n = 13, 49 ± 3 years). Muscle sympathetic nerve activity (MSNA) was directly recorded by microneurography technique. Arterial pressure was measured on a beat-to-beat basis. Time series of MSNA and systolic arterial pressure were analyzed by autoregressive spectral analysis. The gain and time delay of ABRMSNA was obtained by bivariate autoregressive analysis. Exercise training was performed on a cycle ergometer at moderate intensity, three 60-min sessions per week for 16 wk. Baseline MSNA, gain and time delay of ABRMSNA, and low frequency of MSNA (LFMSNA) to high-frequency ratio (HFMSNA) (LFMSNA/HFMSNA) were similar between groups. ET significantly decreased MSNA. MSNA was unchanged in the UT patients. The gain and time delay of ABRMSNA were unchanged in the ET patients. In contrast, the gain of ABRMSNA was significantly reduced [3.5 ± 0.7 vs. 1.8 ± 0.2, arbitrary units (au)/mmHg, P = 0.04] and the time delay of ABRMSNA was significantly increased (4.6 ± 0.8 vs. 7.9 ± 1.0 s, P = 0.05) in the UT patients. LFMSNA-to-HFMSNA ratio tended to be lower in the ET patients (P < 0.08). Exercise training prevents the deterioration of ABRMSNA in CHF patients.

Indexed as

Arterial PressureBaroreflexExercise TherapyAdultAgedBicyclingBrazilCardiovascular SystemChronic DiseaseFemaleHeart FailureHumansMaleMiddle AgedMuscle, SkeletalSympathetic Nervous Systemarterial baroreflex controlchronic heart failureexercise trainingsympathetic modulation

Identifiers

PMID25747752
PMCPMC4551124
OpenAlexW2109559936

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.