Evidence map›Paper›PMID 25755148›Full record

Trial reportVascular medicine (London, England)2015

Community-based walking exercise for peripheral artery disease: An exploratory pilot study.

Ryan J Mays, William R Hiatt, Ivan P Casserly, R Kevin Rogers, Deborah S Main, Wendy M Kohrt, P Michael Ho, Judith G Regensteiner

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Vascular medicine (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 11 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Guideline
  4. Guideline
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Exercise for intermittent claudication.The Cochrane database of systematic reviews · 2017
    Pooled it
  11. Pooled it
  12. Trial
  13. Trial
  14. Trial
  15. The Role of Home-Based Exercise in the Management of Peripheral Artery Disease.Current treatment options in cardiovascular medicine · 2026
    Article
  16. Review
  17. Article
  18. Review
  19. Relation of non-exercise walking activity with exercise performance in patients with peripheral artery disease: NEW activity for PAD.Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ryan J MaysSchool of Physical Therapy and Rehabilitation Science, College of Health Professions and Biomedical Sciences, University of Montana, Missoula, MT, USA The International Heart Institute of Montana Foundation, Saint Patrick Hospital, Providence Medical Group, Missoula, MT, USA Division of General Internal Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA Center for Women's Health Research, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA Ryan.Mays@mso.umt.edu.
William R HiattDivision of Cardiology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA CPC Clinical Research, Aurora, CO, USA.
Ivan P CasserlyMater Private Heart and Vascular Centre, Dublin, Ireland.
R Kevin RogersDivision of Cardiology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA CPC Clinical Research, Aurora, CO, USA.
Deborah S MainDepartment of Health and Behavioral Sciences, University of Colorado Denver, Denver, CO, USA.
Wendy M KohrtCenter for Women's Health Research, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA Division of Geriatric Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
P Michael HoDivision of Cardiology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Judith G RegensteinerDivision of General Internal Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA Center for Women's Health Research, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA Division of Cardiology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3M
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
POSTGRADUATE TRAINING IN CARDIOVASCULAR RESEARCHT32HL007822 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BUTTRICK, PETER N., LEINWAND, LESLIE ANNE · 1996 to 2023
$6.2M
A community-based exercise program to improve walking outcomes in patients with pK01HL115534 · NHLBI · UNIVERSITY OF MONTANA · PI MAYS, RYAN J. · 2012 to 2016
$661k
A community-based exercise program following endovascular therapy for patients wiF32HL105095 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MAYS, RYAN J. · 2011 to 2011
$56k
NCATS NIH HHS UL1 TR001082NCRR NIH HHS UL1 RR025780NHLBI NIH HHS F32 HL105095NHLBI NIH HHS F32HL105095-01A1NHLBI NIH HHS K01 HL115534NHLBI NIH HHS T32 HL007822NHLBI NIH HHS T32HL007822-11A2
6 · The paper itself

Abstract

Supervised walking exercise is an effective treatment to improve walking ability of patients with peripheral artery disease (PAD), but few exercise programs in community settings have been effective. The aim of this study was to determine the efficacy of a community-based walking exercise program with training, monitoring and coaching (TMC) components to improve exercise performance and patient-reported outcomes in PAD patients. This was a randomized, controlled trial including PAD patients (n=25) who previously received peripheral endovascular therapy or presented with stable claudication. Patients randomized to the intervention group received a comprehensive community-based walking exercise program with elements of TMC over 14 weeks. Patients in the control group did not receive treatment beyond standard advice to walk. The primary outcome in the intent-to-treat (ITT) analyses was peak walking time (PWT) on a graded treadmill. Secondary outcomes included claudication onset time (COT) and patient-reported outcomes assessed via the Walking Impairment Questionnaire (WIQ). Intervention group patients (n=10) did not significantly improve PWT when compared with the control group patients (n=10) (mean ± standard error: +2.1 ± 0.7 versus 0.0 ± 0.7 min, p=0.052). Changes in COT and WIQ scores were greater for intervention patients compared with control patients (COT: +1.6 ± 0.8 versus -0.6 ± 0.7 min, p=0.045; WIQ: +18.3 ± 4.2 versus -4.6 ± 4.2%, p=0.001). This pilot using a walking program with TMC and an ITT analysis did not improve the primary outcome in PAD patients. Other walking performance and patient self-reported outcomes were improved following exercise in community settings. Further study is needed to determine whether this intervention improves outcomes in a trial employing a larger sample size.

Indexed as

Community Health ServicesWalkingAgedColoradoCounselingExercise TestExercise TherapyExercise ToleranceFeasibility StudiesFemaleHumansIntention to Treat AnalysisIntermittent ClaudicationMaleMiddle AgedPatient Complianceactivity monitorsclaudicationenvironmental auditunsupervised exercise

Identifiers

PMID25755148
PMCPMC4749131

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.