Evidence map›Paper›PMID 25770704›Full record

Trial reportPsychoneuroendocrinology2015

Improved sleep quality in older adults with insomnia reduces biomarkers of disease risk: pilot results from a randomized controlled comparative efficacy trial.

Judith E Carroll, Teresa E Seeman, Richard Olmstead, Gerson Melendez, Ryan Sadakane, Richard Bootzin, Perry Nicassio, Michael R Irwin

Registry-linked trialOpen access · greenAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychoneuroendocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00280020 (Aging), which is not on this map. Cited by 51 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 4 pooled it
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00280020 nacompletednot on this map

Aging: Cytokine Mechanisms and Treatment of Insomnia

TypeinterventionalSponsorUniversity of California, Los AngelesRan2006 to 2011Enrolled123ConditionsAging, InsomniaArmsTai Chi Chih (TCC), Cognitive Behavior Therapy (CBT), Sleep Seminar (SS)
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 4 syntheses or guidelines pooled it, 128 citations in OpenAlex.

  1. Pooled it
  2. Health benefits of tai chi: What is the evidence?Canadian family physician Medecin de famille canadien · 2016
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  18. Allostatic Load, Morbidity, and Mortality Among Older Adults: A Multi-Wave Analysis From the National Health and Aging Trends Study.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Judith E CarrollUniversity of California, Los Angeles-Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA; University of California, Los Angeles, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, Los Angeles, CA, USA. Electronic address: jcarroll@mednet.ucla.edu.
Teresa E SeemanUniversity of California, Los Angeles, Division of Geriatrics, David Geffen School of Medicine, Los Angeles, CA, USA.
Richard OlmsteadUniversity of California, Los Angeles-Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA; University of California, Los Angeles, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, Los Angeles, CA, USA.
Gerson MelendezUniversity of California, Los Angeles-Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA; University of California, Los Angeles, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, Los Angeles, CA, USA.
Ryan SadakaneUniversity of California, Los Angeles-Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA; University of California, Los Angeles, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, Los Angeles, CA, USA.
Richard BootzinUniversity of Arizona, Department of Psychology, Tucson, AZ, USA.
Perry NicassioUniversity of California, Los Angeles-Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
Michael R IrwinUniversity of California, Los Angeles-Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA; University of California, Los Angeles, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, Los Angeles, CA, USA. Electronic address: mirwin1@ucla.edu.
University of California, Los Angeles · USUniversity of Arizona · US

Funding

Aging: Cytokine Mechanisms and Treatment of InsomniaR01AG026364 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2005 to 2005
$439k
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCI NIH HHS R01 CA119159NCI NIH HHS R01-CA119159NCRR NIH HHS UL1 RR033176NHLBI NIH HHS R01 HL079955NHLBI NIH HHS R01-HL079955NHLBI NIH HHS R01 HL095799NIA NIH HHS K01 AG044462NIA NIH HHS K01-AG044462NIA NIH HHS P30 AG028748NIA NIH HHS P30-AG028748NIA NIH HHS R01 AG026364NIA NIH HHS R01 AG034588PHS HHS UL ULRR 033176
6 · The paper itself

Abstract

importanceSleep disturbances have been linked to increased morbidity and mortality, yet it is unknown whether improving sleep quality in older adult patients with insomnia alters biomarkers of diabetes and cardiovascular disease risk.

objectiveDetermine the comparative efficacy of cognitive behavioral therapy (CBT), tai chi chih (TCC), and a sleep seminar control (SS) to reduce multisystem biomarkers of disease risk in older adults with insomnia.

designRandomized controlled comparative efficacy trial.

settingLos Angeles community.

participantsA population-based sample of 109 older adults with chronic and primary insomnia.

interventionRandom assignment to CBT, TCC, or SS for 2-h group sessions weekly over 4 months with a 16-month evaluation (1 year after follow-up). MAIN OUTCOME(S) AND MEASURE(S): Multisystem biological risk comprised of 8 biomarkers: high-density lipoprotein, low-density lipoprotein, triglycerides, hemoglobinA1c, glucose, insulin, C-reactive protein, and fibrinogen. Using clinical laboratory cutoffs defined as abnormal, a multisystem risk score was computed representing a sum of the deviation around the cutoffs across the 8 biomarkers. In addition, high risk grouping was classified if subjects exhibited 4 or more biomarkers in the abnormal laboratory range.

resultsAn interaction of time-by-treatment-by-high risk group was found (F(4, 197.2)=3.14, p=.02) in which both TCC (p=.04) and CBT (p=.001) showed significantly lower risk scores as compared to SS at 16-months. CBT reduced risk of being in the high risk group at 4-months (odds ratio [OR]=.21 [95% CI, .03-1.47], p<.10) and at 16-months (OR=.06 [95% CI, .005-.669]; p<.01). TCC reduced the risk at 16-months (OR=.10 [95% CI, .008-1.29]; p<.05) but not at 4 months. Of participants who were classified in the high risk category at baseline, improvements in sleep quality, as defined by a clinical severity threshold, reduced the likelihood of being in the high risk group at 16-months, OR=.08 (95% CI, .008-.78); p=.01. CONCLUSIONS AND RELEVANCE: Participants classified as having high multisystem biological risk at entry and assigned to CBT or TCC show improvements in risk scores after one year follow-up. Given that these clinical biomarkers are associated with cardiovascular, metabolic, and inflammatory disease risk, improving sleep quality has the potential to reduce the risk of chronic disease in older adults with insomnia. Clinical Trial Registration # and name—ClinicalTrials.gov: NCT00280020, Behavioral Treatment of Insomnia in Aging

Indexed as

AgedAllostasisBiomarkersBlood GlucoseCardiovascular DiseasesCholesterol, HDLCholesterol, LDLCognitive Behavioral TherapyC-Reactive ProteinDiabetes MellitusFemaleFibrinogenGlycated HemoglobinHumansInsulinMaleBiomarkersBlood GlucoseCholesterol, HDLCholesterol, LDLC-Reactive ProteinFibrinogenGlycated Hemoglobinhemoglobin A1c protein, humanInsulinTriglyceridesAllostatic loadClinicalTrials.gov: NCT00280020, Behavioral Treatment of Insomnia in AgingDisease riskInsomniaInterventionMultisystemSleep

Identifiers

PMID25770704
PMCPMC4422640
OpenAlexW2076339079

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.