Evidence map›Paper›PMID 25795378›Full record

ReviewBrain research2015

SIRP/CD47 signaling in neurological disorders.

Haiyue Zhang, Fengwu Li, Yuanyuan Yang, Jun Chen, Xiaoming Hu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 71 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Haiyue ZhangCenter of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Xianaya School of Medicine, Central South University, Changsha, Hunan, China.
Fengwu LiChina-America Institute of Neuroscience, Luhe Teaching Hospital, Capital Medical University, Beijing, China.
Yuanyuan YangCenter of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Xianaya School of Medicine, Central South University, Changsha, Hunan, China.
Jun ChenCenter of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address: chenj2@upmc.edu.
Xiaoming HuCenter of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; China-America Institute of Neuroscience, Luhe Teaching Hospital, Capital Medical University, Beijing, China. Electronic address: hux2@upmc.edu.
Central South University · CNUniversity of Pittsburgh · USBeijing Luhe Hospital Affiliated to Capital Medical University · CN

Funding

INDUCIBLE DNA REPAIR IN CEREBRAL ISCHEMIAR01NS036736 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENNETT, MICHAEL V L, GRAHAM, STEVEN H · 1997 to 2021
$5.4M
Neuroprotection in Models of Cerebral IschemiaR01NS045048 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, JUN · 2003 to 2015
$3.1M
Programmed Cell Death Induced by Cerebral IschemiaR01NS043802 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, JUN · 2002 to 2006
$1.4M
NINDS NIH HHS NS36736NINDS NIH HHS NS43802NINDS NIH HHS NS45048NINDS NIH HHS R01 NS036736NINDS NIH HHS R01 NS043802NINDS NIH HHS R01 NS045048
6 · The paper itself

Abstract

Microglia play important roles in the process of neuronal injury and recovery. Numeous surface receptors have been described to regulate microglial activation. These receptors tightly mediate normal microglial functions including cell mobility, phagocytosis, and production of inflammatory mediators or trophic factors. In recent years, significant progresses have been achieved for understanding the signaling mechanisms underlying these receptors. Their specific roles in neurological diseases have been documented. This review will focus on the signal regulatory protein (SIRP) and its ligand CD47, two surface receptors expressed on microglia and other cells in the central nervous system (CNS) such as neurons. We will discuss the involvement of SIRP/CD47 signaling in microglial activation and in the interplay between microglia and other CNS cells. Current studies reveal the importance of CD47 and SIRPα in the process of neuroinflammation in the CNS disorders. The dual and contradictory role of CD47 suggests that targeting the SIRPα/CD47 signaling may achieve different effects depending on disease stage. This article is part of a Special Issue entitled SI: Cell Interactions In Stroke.

Indexed as

AnimalsCD47 AntigenCentral Nervous System DiseasesHumansMicrogliaNeuroimmunomodulationReceptors, ImmunologicSignal TransductionCD47 AntigenReceptors, ImmunologicCD47MicrogliaNeuroinflammationSignal regulatory protein (SIRP)

Identifiers

PMID25795378
PMCPMC4569528
OpenAlexW2045282691

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.