Evidence map›Paper›PMID 25810256›Full record

ArticleAmerican journal of physiology. Cell physiology2015

Chronic disuse and skeletal muscle structure in older adults: sex-specific differences and relationships to contractile function.

Damien M Callahan, Timothy W Tourville, Mark S Miller, Sarah B Hackett, Himani Sharma, Nicholas C Cruickshank, James R Slauterbeck, Patrick D Savage, Philip A Ades, David W Maughan and 2 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01190046 (Muscle Disuse and Contractile Dysfunction in the Elderly), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01190046 nacompletednot on this map

Muscle Disuse and Contractile Dysfunction in the Elderly

TypeinterventionalSponsorUniversity of VermontRan2010 to 2016Enrolled35ConditionsOsteoarthritisArmsResistance exercise training
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
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  3. Trial
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  7. Article
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  12. Review
  13. Sex Differences in Inflammation and Muscle Wasting in Aging and Disease.International journal of molecular sciences · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Damien M CallahanDepartment of Medicine, College of Medicine, University of Vermont, Burlington, Vermont;
Timothy W TourvilleDepartment of Orthopaedics and Rehabilitation, College of Medicine, University of Vermont, Burlington, Vermont.
Mark S MillerDepartment of Molecular Physiology and Biophysics, College of Medicine, University of Vermont, Burlington, Vermont; and.
Sarah B HackettDepartment of Medicine, College of Medicine, University of Vermont, Burlington, Vermont;
Himani SharmaDepartment of Medicine, College of Medicine, University of Vermont, Burlington, Vermont;
Nicholas C CruickshankDepartment of Medicine, College of Medicine, University of Vermont, Burlington, Vermont;
James R SlauterbeckDepartment of Orthopaedics and Rehabilitation, College of Medicine, University of Vermont, Burlington, Vermont.
Patrick D SavageDepartment of Medicine, College of Medicine, University of Vermont, Burlington, Vermont;
Philip A AdesDepartment of Medicine, College of Medicine, University of Vermont, Burlington, Vermont;
David W MaughanDepartment of Molecular Physiology and Biophysics, College of Medicine, University of Vermont, Burlington, Vermont; and.
Bruce D BeynnonDepartment of Orthopaedics and Rehabilitation, College of Medicine, University of Vermont, Burlington, Vermont.
Michael J TothDepartment of Medicine, College of Medicine, University of Vermont, Burlington, Vermont; Department of Molecular Physiology and Biophysics, College of Medicine, University of Vermont, Burlington, Vermont; and michael.toth@uvm.edu.
University of Vermont · US

Funding

POST-DOCTORAL CARDIOVASCULAR RESEARCH TRAINING PROGRAMT32HL007647 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI LEWINTER, MARTIN M · 1988 to 2013
$3.3M
Muscle disuse and contractile dysfunction in the elderlyR01AG033547 · NIA · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI TOTH, MICHAEL J · 2010 to 2014
$1.9M
Single Skeletal Muscle Fiber Mechanics and Myosin Kinetics in Human AgingK01AG031303 · NIA · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI MILLER, MARK STUART · 2008 to 2012
$611k
NHLBI NIH HHS HL-007647NHLBI NIH HHS T32 HL007647NIA NIH HHS AG-031303NIA NIH HHS AG-033547NIA NIH HHS K01 AG031303NIA NIH HHS R01 AG033547
6 · The paper itself

Abstract

In older adults, we examined the effect of chronic muscle disuse on skeletal muscle structure at the tissue, cellular, organellar, and molecular levels and its relationship to muscle function. Volunteers with advanced-stage knee osteoarthritis (OA, n = 16) were recruited to reflect the effects of chronic lower extremity muscle disuse and compared with recreationally active controls (n = 15) without knee OA but similar in age, sex, and health status. In the OA group, quadriceps muscle and single-fiber cross-sectional area were reduced, with the largest reduction in myosin heavy chain IIA fibers. Myosin heavy chain IIAX fibers were more prevalent in the OA group, and their atrophy was sex-specific: men showed a reduction in cross-sectional area, and women showed no differences. Myofibrillar ultrastructure, myonuclear content, and mitochondrial content and morphology generally did not differ between groups, with the exception of sex-specific adaptations in subsarcolemmal (SS) mitochondria, which were driven by lower values in OA women. SS mitochondrial content was also differently related to cellular and molecular functional parameters by sex: greater SS mitochondrial content was associated with improved contractility in women but reduced function in men. Collectively, these results demonstrate sex-specific structural phenotypes at the cellular and organellar levels with chronic disuse in older adults, with novel associations between energetic and contractile systems.

Indexed as

Muscle ContractionAgedCase-Control StudiesExerciseFemaleGene ExpressionHumansKneeMaleMitochondriaMuscle Fibers, SkeletalMuscular AtrophyMyosin Heavy ChainsOsteoarthritis, KneeProtein IsoformsQuadriceps MuscleMyosin Heavy ChainsProtein Isoformsmitochondriamyosinphysical activityultrastructure

Identifiers

PMID25810256
PMCPMC4451348
OpenAlexW2029487926

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.