Evidence map›Paper›PMID 25819039›Full record

ReviewBone2015

Epigenetic histone modifications and master regulators as determinants of context dependent nuclear receptor activity in bone cells.

J Wesley Pike, Mark B Meyer, Hillary C St John, Nancy A Benkusky

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bone, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Enhancer of zeste homolog 2 (The Journal of biological chemistry · 2018
    Article
  13. Article
  14. Biology and Mechanisms of Action of the Vitamin D Hormone.Endocrinology and metabolism clinics of North America · 2017
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

J Wesley PikeDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address: pike@biochem.wisc.edu.
Mark B MeyerDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Hillary C St JohnDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Nancy A BenkuskyDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
University of Wisconsin–Madison · US

Funding

Molecular Mechanisms of RANKL Activation in OsteoblastsR01DK074993 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI PIKE, J WESLEY · 2007 to 2017
$4.0M
BONE CELL REGULATION OF THE VITAMIN D RECEPTOR GENER01AR045173 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI PIKE, J WESLEY · 1999 to 2015
$3.5M
Dynamic Mechanisms of Vitamin D-Induced Gene ExpressionR01DK072281 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI PIKE, J WESLEY · 2005 to 2012
$2.6M
Integrative genomics to define osteocyte differentiation, regulation and functionR01AR064424 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI PIKE, J WESLEY · 2014 to 2018
$1.7M
NIAMS NIH HHS AR-045173NIAMS NIH HHS AR-062442NIAMS NIH HHS R01 AR045173NIAMS NIH HHS R01 AR064424NIDDK NIH HHS DK-072281NIDDK NIH HHS DK-074993NIDDK NIH HHS R01 DK072281NIDDK NIH HHS R01 DK074993
6 · The paper itself

Abstract

Genomic annotation of unique and combinatorial epigenetic modifications along with transcription factor occupancy is having a profound impact on our understanding of the genome. These studies have led to a better appreciation of the dynamic nature of the epigenetic and transcription factor binding components that reveal overarching principles of the genome as well as tissue specificity. In this minireview, we discuss the presence and potential functions of several of these features across the genome in osteoblast lineage cells. We examine how these features are modulated during cellular maturation, affect transcriptional output and phenotype, and how they alter the ability of cells to respond to systemic signals directed by calcemic hormones such as 1,25-dihydroxyvitamin D3 and PTH. In particular, we describe recent experiments which indicate that progressive stages of bone cell differentiation affect RUNX2 binding to the genome, modify and restrict patterns of gene expression, and dramatically alter cellular response to the vitamin D hormone. These studies expand our understanding of mechanisms that govern steroid hormone regulation of gene expression, while highlighting the increasing complexity that is evident relative to these basic cellular processes. The results also have profound implications with respect to the impact of skeletal diseases on transcriptional outcomes as well. This article is part of a Special Issue entitled Epigenetics and Bone.

Indexed as

Epigenesis, GeneticAnimalsBone and BonesCalcitriolCCAAT-Enhancer-Binding Protein-betaCell DifferentiationCore Binding Factor Alpha 1 SubunitHistone CodeHumansModels, BiologicalOsteoblastsParathyroid HormoneReceptors, CalcitriolReceptors, Cytoplasmic and NuclearCalcitriolCCAAT-Enhancer-Binding Protein-betaCore Binding Factor Alpha 1 SubunitParathyroid HormoneReceptors, CalcitriolReceptors, Cytoplasmic and NuclearEpigeneticsGenome-wide analysisOsteoblast lineage cellsTranscription

Identifiers

PMID25819039
PMCPMC4584159
OpenAlexW2129769007

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.