ArticlePloS one2015
The identification of loci for immune traits in chickens using a genome-wide association study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Genome-wide association study reveals loci associated with cytokine levels in chicken serum.Poultry science · 2026Article
- Experimental change in temperament: Conversion of the low exploratory phenotype into highly explorative by overexpression of GDNF in the rat striatum.Molecular psychiatry · 2026Article
- Genome-Wide Association Study of Immune Indices in Yaks.Animals : an open access journal from MDPI · 2025Article
- Identification of Resistance Loci to Avian Leukosis via Genome-Wide Association Analysis in Chengkou Mountain Chickens.Animals : an open access journal from MDPI · 2025Article
- Effect of dietary betaine supplementation on the liver transcriptome profile in broiler chickens under heat stress conditions.Animal bioscience · 2023Article
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- Transcriptomic Analysis of the Spleen of Different Chicken Breeds Revealed the Differential Resistance ofGenes · 2022Article
- High Levels of Genetic Variation in MHC-Linked Microsatellite Markers from Native Chicken Breeds.Genes · 2021Article
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- Genome-Wide Association Study of Growth Performance and Immune Response to Newcastle Disease Virus of Indigenous Chicken in Rwanda.Frontiers in genetics · 2021Article
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- A genome-wide association study explores the genetic determinism of host resistance to Salmonella pullorum infection in chickens.Genetics, selection, evolution : GSE · 2019Article
- Genetic Mutation Analysis of High and Low IgY Chickens by Capture Sequencing.Animals : an open access journal from MDPI · 2019Article
- Genome-Wide Association Study of H/L Traits in Chicken.Animals : an open access journal from MDPI · 2019Article
- Article
- Genome-wide association study of body weight in Wenshang Barred chicken based on the SLAF-seq technology.Journal of applied genetics · 2018Review
- Genomic prediction of avian influenza infection outcome in layer chickens.Genetics, selection, evolution : GSE · 2018Article
- Annotating long intergenic non-coding RNAs under artificial selection during chicken domestication.BMC evolutionary biology · 2017Article
- Genome-wide standing variation facilitates long-term response to bidirectional selection for antibody response in chickens.BMC genomics · 2017Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genetic improvement of disease resistance in poultry continues to be a challenge. To identify candidate genes and loci responsible for these traits, genome-wide association studies using the chicken 60k high density single nucleotide polymorphism (SNP) array for six immune traits, total serum immunoglobulin Y (IgY) level, numbers of, and the ratio of heterophils and lymphocytes, and antibody responses against Avian Influenza Virus (AIV) and Sheep Red Blood Cell (SRBC), were performed. RT-qPCR was used to quantify the relative expression of the identified candidate genes. Nine significantly associated SNPs (P < 2.81E-06) and 30 SNPs reaching the suggestively significant level (P < 5.62E-05) were identified. Five of the 10 SNPs that were suggestively associated with the antibody response to SRBC were located within or close to previously reported QTL regions. Fifteen SNPs reached a suggestive significance level for AIV antibody titer and seven were found on the sex chromosome Z. Seven suggestive markers involving five different SNPs were identified for the numbers of heterophils and lymphocytes, and the heterophil/lymphocyte ratio. Nine significant SNPs, all on chromosome 16, were significantly associated with serum total IgY concentration, and the five most significant were located within a narrow region spanning 6.4kb to 253.4kb (P = 1.20E-14 to 5.33E-08). After testing expression of five candidate genes (IL4I1, CD1b, GNB2L1, TRIM27 and ZNF692) located in this region, changes in IL4I1, CD1b transcripts were consistent with the concentrations of IgY, while abundances of TRIM27 and ZNF692 showed reciprocal changes to those of IgY concentrations. This study has revealed 39 SNPs associated with six immune traits (total serum IgY level, numbers of, and the ratio of heterophils and lymphocytes, and antibody responses against AIV and SRBC) in Beijing-You chickens. The narrow region spanning 247kb on chromosome 16 is an important QTL for serum total IgY concentration. Five candidate genes related to IgY level validated here are novel and may play critical roles in the modulation of immune responses. Potentially useful candidate SNPs for marker-assisted selection for disease resistance are identified. It is highly likely that these candidate genes play roles in various aspects of the immune response in chickens.
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