TrialCirculation2015

High-sensitivity cardiac troponin I and B-type natriuretic Peptide as predictors of vascular events in primary prevention: impact of statin therapy.

Brendan M Everett et al.PubMed ↗Full text ↗Publisher ↗

Highest tertile of hsTnIlooks bad hereMore deaths.Correlation only, not a test of it.
Highest tertile of BNPlooks bad hereMore deaths.Correlation only, not a test of it.

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Highest tertile of hsTnI went with more deaths

2.6×1.8× to 3.8×

highest tertile of hsTnI vs lowest tertile of hsTnI

Bigger than almost all for all-cause mortality

As reported

HR 2.61, 95% CI 1.81–3.78 · the paper's word: all-cause mortality

Correlation, not cause

Highest tertile of BNP went with more deaths

1.4×1× to 2×

highest tertile of BNP vs lowest tertile of BNP

Bigger than 8 in 10 for all-cause mortality

As reported

HR 1.45, 95% CI 1.03–2.04 · the paper's word: all-cause mortality

Who was studied, and how

17,802people in the A Randomized, Double-Blind, Placebo Controlled, Multicenter, Phase 3 Study of Rosuvastatin trial, from 2003

76of them with cardiovascular disease, in this paper

Already taking highest tertile of hsTnI, or nottheir own situation, not assigned

on highest tertile of hsTnI

lowest tertile of hsTnI

Highest tertile of hsTnI went with more deaths2.6×

correlation, not a test

Already taking highest tertile of BNP, or nottheir own situation, not assigned

on highest tertile of BNP

lowest tertile of BNP

Highest tertile of BNP went with more deaths1.4×

correlation, not a test

the abstract, start to end

… the lowest tertiles of hsTnI (aHR, 2.61; 95% confidence interval, 1.81-3.78; P for trend <0.001) and BNP (aHR, 1.45; 95% confidence interval, …

← favours treatmentfavours comparator →

could be chance

All-cause mortalityhighest tertile of hsTnI vs lowest tertile of hsTnI

HR 2.611.81–3.78

All-cause mortalityhighest tertile of BNP vs lowest tertile of BNP

HR 1.451.03–2.04

StatinsAll-cause mortality

1 / 4

59 papers cite it

2015

2016

2017

2018

2019

2020

2021

2022

2023

2024

2025

2026

this paperpooled ittrialcites it

The trial

NCT00239681phase 317,802 enrolled2003