Evidence map›Paper›PMID 25833893›Full record

ReviewThe Journal of nutrition2015

Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE).

Daniel J Raiten, Fayrouz A Sakr Ashour, A Catharine Ross, Simin N Meydani, Harry D Dawson, Charles B Stephensen, Bernard J Brabin, Parminder S Suchdev, Ben van Ommen, INSPIRE Consultative Group

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Micronutrient supplementation in adults with HIV infection.The Cochrane database of systematic reviews · 2017
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  15. Malaria early in the first pregnancy: Potential impact of iron status.Clinical nutrition (Edinburgh, Scotland) · 2020
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72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniel J RaitenEunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD; raitend@mail.nih.gov.
Fayrouz A Sakr AshourEunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD;
A Catharine RossDepartments of Nutritional Sciences and Veterinary and Biomedical Science and Center for Molecular Immunology and Infectious Disease, Pennsylvania State University, University Park, PA;
Simin N MeydaniJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA;
Harry D DawsonUSDA-Agricultural Research Service, Beltsville Human Nutrition Research Center, Diet, Genomics, and Immunology Laboratory, Beltsville, MD;
Charles B StephensenAgricultural Research Service, Western Human Nutrition Research Center, USDA, Davis, CA;
Bernard J BrabinChild and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; Global Child Health Group, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands;
Parminder S SuchdevDepartment of Pediatrics and Global Health, Emory University, Atlanta, GA; and.
Ben van OmmenTNO, Zeist, The Netherlands.
INSPIRE Consultative Group

Funding

Vitamin A Supplementation and Retinol Metabolism in the Neonatal PeriodR01HD066982 · NICHD · PENNSYLVANIA STATE UNIVERSITY, THE · PI ROSS, A. CATHARINE · 2010 to 2019
$2.9M
Vitamin A mediated protection from gastrointestinal infectionR56AI114972 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI CANTORNA, MARGHERITA T, ROSS, A. CATHARINE · 2015 to 2015
$477k
Retinoid Nutritional Status and Immune FunctionR56DK041479 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI ROSS, A. CATHARINE · 2012 to 2012
$158k
NIAID NIH HHS R56 AI114972NICHD NIH HHS R01 HD066982NIDDK NIH HHS R56 DK041479
6 · The paper itself

Abstract

An increasing recognition has emerged of the complexities of the global health agenda—specifically, the collision of infections and noncommunicable diseases and the dual burden of over- and undernutrition. Of particular practical concern are both 1) the need for a better understanding of the bidirectional relations between nutritional status and the development and function of the immune and inflammatory response and 2) the specific impact of the inflammatory response on the selection, use, and interpretation of nutrient biomarkers. The goal of the Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE) is to provide guidance for those users represented by the global food and nutrition enterprise. These include researchers (bench and clinical), clinicians providing care/treatment, those developing and evaluating programs/interventions at scale, and those responsible for generating evidence-based policy. The INSPIRE process included convening 5 thematic working groups (WGs) charged with developing summary reports around the following issues: 1) basic overview of the interactions between nutrition, immune function, and the inflammatory response; 2) examination of the evidence regarding the impact of nutrition on immune function and inflammation; 3) evaluation of the impact of inflammation and clinical conditions (acute and chronic) on nutrition; 4) examination of existing and potential new approaches to account for the impact of inflammation on biomarker interpretation and use; and 5) the presentation of new approaches to the study of these relations. Each WG was tasked with synthesizing a summary of the evidence for each of these topics and delineating the remaining gaps in our knowledge. This review consists of a summary of the INSPIRE workshop and the WG deliberations.

Indexed as

Congresses as TopicEvidence-Based MedicineGlobal HealthImmunologic TechniquesAnimalsBiomarkersBiomedical ResearchDietFood TechnologyHumansInflammation MediatorsNutritional SciencesNutrition PolicyTerminology as TopicBiomarkersInflammation Mediatorsassessment of micronutrient biomarkersBOND and inflammation/infectionimmune function and nutrientsinflammation and nutritionnutrition biomarkers

Identifiers

PMID25833893
PMCPMC4448820

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.