Evidence map›Paper›PMID 25844619›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2015

The Effect of a Whey Protein Supplement on Bone Mass in Older Caucasian Adults.

Jane E Kerstetter, Jessica D Bihuniak, Jennifer Brindisi, Rebecca R Sullivan, Kelsey M Mangano, Sarah Larocque, Belinda M Kotler, Christine A Simpson, Anna Maria Cusano, Erin Gaffney-Stomberg and 5 more

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 10 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 10 syntheses or guidelines pooled it, 82 citations in OpenAlex.

  1. Pooled it
  2. The skeletal safety of milk-derived proteins: A meta-analysis of randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
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  9. Dietary protein and bone health across the life-course: an updated systematic review and meta-analysis over 40 years.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
    Pooled it
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  17. High protein consumption in trained women: bad to the bone?Journal of the International Society of Sports Nutrition · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Jane E KerstetterDepartment of Allied Health Sciences (J.E.K., J.D.B., S.L., B.M.K., E.G.-S.), University of Connecticut, Storrs, Connecticut 06269-1101; Center on Aging (A.M.K., J.B., A.K.), University of Connecticut Health Center, Farmington, Connecticut 06030; Department of Internal Medicine (J.D.B., R.R.S., C.A.S., A.M.C., E.G.-S., K.L.I.), Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520; Institute for Aging Research (K.M.M.), Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts 02114; and Yale Center for Analytical Sciences (J.R., J.D.), Yale School of Public Health, Yale University, New Haven, Connecticut 06510.
Jessica D BihuniakDepartment of Allied Health Sciences (J.E.K., J.D.B., S.L., B.M.K., E.G.-S.), University of Connecticut, Storrs, Connecticut 06269-1101; Center on Aging (A.M.K., J.B., A.K.), University of Connecticut Health Center, Farmington, Connecticut 06030; Department of Internal Medicine (J.D.B., R.R.S., C.A.S., A.M.C., E.G.-S., K.L.I.), Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520; Institute for Aging Research (K.M.M.), Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts 02114; and Yale Center for Analytical Sciences (J.R., J.D.), Yale School of Public Health, Yale University, New Haven, Connecticut 06510.
Jennifer BrindisiDepartment of Allied Health Sciences (J.E.K., J.D.B., S.L., B.M.K., E.G.-S.), University of Connecticut, Storrs, Connecticut 06269-1101; Center on Aging (A.M.K., J.B., A.K.), University of Connecticut Health Center, Farmington, Connecticut 06030; Department of Internal Medicine (J.D.B., R.R.S., C.A.S., A.M.C., E.G.-S., K.L.I.), Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520; Institute for Aging Research (K.M.M.), Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts 02114; and Yale Center for Analytical Sciences (J.R., J.D.), Yale School of Public Health, Yale University, New Haven, Connecticut 06510.
Rebecca R SullivanDepartment of Allied Health Sciences (J.E.K., J.D.B., S.L., B.M.K., E.G.-S.), University of Connecticut, Storrs, Connecticut 06269-1101; Center on Aging (A.M.K., J.B., A.K.), University of Connecticut Health Center, Farmington, Connecticut 06030; Department of Internal Medicine (J.D.B., R.R.S., C.A.S., A.M.C., E.G.-S., K.L.I.), Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520; Institute for Aging Research (K.M.M.), Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts 02114; and Yale Center for Analytical Sciences (J.R., J.D.), Yale School of Public Health, Yale University, New Haven, Connecticut 06510.
Kelsey M ManganoDepartment of Allied Health Sciences (J.E.K., J.D.B., S.L., B.M.K., E.G.-S.), University of Connecticut, Storrs, Connecticut 06269-1101; Center on Aging (A.M.K., J.B., A.K.), University of Connecticut Health Center, Farmington, Connecticut 06030; Department of Internal Medicine (J.D.B., R.R.S., C.A.S., A.M.C., E.G.-S., K.L.I.), Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520; Institute for Aging Research (K.M.M.), Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts 02114; and Yale Center for Analytical Sciences (J.R., J.D.), Yale School of Public Health, Yale University, New Haven, Connecticut 06510.
Sarah LarocqueDepartment of Allied Health Sciences (J.E.K., J.D.B., S.L., B.M.K., E.G.-S.), University of Connecticut, Storrs, Connecticut 06269-1101; Center on Aging (A.M.K., J.B., A.K.), University of Connecticut Health Center, Farmington, Connecticut 06030; Department of Internal Medicine (J.D.B., R.R.S., C.A.S., A.M.C., E.G.-S., K.L.I.), Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520; Institute for Aging Research (K.M.M.), Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts 02114; and Yale Center for Analytical Sciences (J.R., J.D.), Yale School of Public Health, Yale University, New Haven, Connecticut 06510.
Belinda M KotlerDepartment of Allied Health Sciences (J.E.K., J.D.B., S.L., B.M.K., E.G.-S.), University of Connecticut, Storrs, Connecticut 06269-1101; Center on Aging (A.M.K., J.B., A.K.), University of Connecticut Health Center, Farmington, Connecticut 06030; Department of Internal Medicine (J.D.B., R.R.S., C.A.S., A.M.C., E.G.-S., K.L.I.), Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520; Institute for Aging Research (K.M.M.), Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts 02114; and Yale Center for Analytical Sciences (J.R., J.D.), Yale School of Public Health, Yale University, New Haven, Connecticut 06510.
Christine A SimpsonDepartment of Allied Health Sciences (J.E.K., J.D.B., S.L., B.M.K., E.G.-S.), University of Connecticut, Storrs, Connecticut 06269-1101; Center on Aging (A.M.K., J.B., A.K.), University of Connecticut Health Center, Farmington, Connecticut 06030; Department of Internal Medicine (J.D.B., R.R.S., C.A.S., A.M.C., E.G.-S., K.L.I.), Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520; Institute for Aging Research (K.M.M.), Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts 02114; and Yale Center for Analytical Sciences (J.R., J.D.), Yale School of Public Health, Yale University, New Haven, Connecticut 06510.
Anna Maria CusanoDepartment of Allied Health Sciences (J.E.K., J.D.B., S.L., B.M.K., E.G.-S.), University of Connecticut, Storrs, Connecticut 06269-1101; Center on Aging (A.M.K., J.B., A.K.), University of Connecticut Health Center, Farmington, Connecticut 06030; Department of Internal Medicine (J.D.B., R.R.S., C.A.S., A.M.C., E.G.-S., K.L.I.), Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520; Institute for Aging Research (K.M.M.), Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts 02114; and Yale Center for Analytical Sciences (J.R., J.D.), Yale School of Public Health, Yale University, New Haven, Connecticut 06510.
Erin Gaffney-StombergDepartment of Allied Health Sciences (J.E.K., J.D.B., S.L., B.M.K., E.G.-S.), University of Connecticut, Storrs, Connecticut 06269-1101; Center on Aging (A.M.K., J.B., A.K.), University of Connecticut Health Center, Farmington, Connecticut 06030; Department of Internal Medicine (J.D.B., R.R.S., C.A.S., A.M.C., E.G.-S., K.L.I.), Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520; Institute for Aging Research (K.M.M.), Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts 02114; and Yale Center for Analytical Sciences (J.R., J.D.), Yale School of Public Health, Yale University, New Haven, Connecticut 06510.
Alison KleppingerDepartment of Allied Health Sciences (J.E.K., J.D.B., S.L., B.M.K., E.G.-S.), University of Connecticut, Storrs, Connecticut 06269-1101; Center on Aging (A.M.K., J.B., A.K.), University of Connecticut Health Center, Farmington, Connecticut 06030; Department of Internal Medicine (J.D.B., R.R.S., C.A.S., A.M.C., E.G.-S., K.L.I.), Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520; Institute for Aging Research (K.M.M.), Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts 02114; and Yale Center for Analytical Sciences (J.R., J.D.), Yale School of Public Health, Yale University, New Haven, Connecticut 06510.
Jesse ReynoldsDepartment of Allied Health Sciences (J.E.K., J.D.B., S.L., B.M.K., E.G.-S.), University of Connecticut, Storrs, Connecticut 06269-1101; Center on Aging (A.M.K., J.B., A.K.), University of Connecticut Health Center, Farmington, Connecticut 06030; Department of Internal Medicine (J.D.B., R.R.S., C.A.S., A.M.C., E.G.-S., K.L.I.), Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520; Institute for Aging Research (K.M.M.), Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts 02114; and Yale Center for Analytical Sciences (J.R., J.D.), Yale School of Public Health, Yale University, New Haven, Connecticut 06510.
James DziuraDepartment of Allied Health Sciences (J.E.K., J.D.B., S.L., B.M.K., E.G.-S.), University of Connecticut, Storrs, Connecticut 06269-1101; Center on Aging (A.M.K., J.B., A.K.), University of Connecticut Health Center, Farmington, Connecticut 06030; Department of Internal Medicine (J.D.B., R.R.S., C.A.S., A.M.C., E.G.-S., K.L.I.), Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520; Institute for Aging Research (K.M.M.), Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts 02114; and Yale Center for Analytical Sciences (J.R., J.D.), Yale School of Public Health, Yale University, New Haven, Connecticut 06510.
Anne M KennyDepartment of Allied Health Sciences (J.E.K., J.D.B., S.L., B.M.K., E.G.-S.), University of Connecticut, Storrs, Connecticut 06269-1101; Center on Aging (A.M.K., J.B., A.K.), University of Connecticut Health Center, Farmington, Connecticut 06030; Department of Internal Medicine (J.D.B., R.R.S., C.A.S., A.M.C., E.G.-S., K.L.I.), Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520; Institute for Aging Research (K.M.M.), Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts 02114; and Yale Center for Analytical Sciences (J.R., J.D.), Yale School of Public Health, Yale University, New Haven, Connecticut 06510.
Karl L InsognaDepartment of Allied Health Sciences (J.E.K., J.D.B., S.L., B.M.K., E.G.-S.), University of Connecticut, Storrs, Connecticut 06269-1101; Center on Aging (A.M.K., J.B., A.K.), University of Connecticut Health Center, Farmington, Connecticut 06030; Department of Internal Medicine (J.D.B., R.R.S., C.A.S., A.M.C., E.G.-S., K.L.I.), Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520; Institute for Aging Research (K.M.M.), Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts 02114; and Yale Center for Analytical Sciences (J.R., J.D.), Yale School of Public Health, Yale University, New Haven, Connecticut 06510.
Yale University · USUniversity of Connecticut · USUConn Health · USHarvard University · US

Funding

NIAMS NIH HHS AR0537
6 · The paper itself

Abstract

contextIt has been assumed that the increase in urine calcium (Ca) that accompanies an increase in dietary protein was due to increased bone resorption. However, studies using stable Ca isotopes have found that dietary protein increases Ca absorption without increasing bone resorption.

objectiveThe objective of the study was to investigate the impact of a moderately high protein diet on bone mineral density (BMD).

designThis was a randomized, double-blind, placebo-controlled trial of protein supplementation daily for 18 months.

settingThe study was conducted at two institutional research centers.

participantsTwo hundred eight older women and men with a body mass index between 19 and 32 kg/m(2) and a self-reported protein intake between 0.6 and 1.0 g/kg participated in the study.

interventionSubjects were asked to incorporate either a 45-g whey protein or isocaloric maltodextrin supplement into their usual diet for 18 months.

main outcome measureBMD by dual-energy x-ray absorptiometry, body composition, and markers of skeletal and mineral metabolism were measured at baseline and at 9 and 18 months.

resultsThere were no significant differences between groups for changes in L-spine BMD (primary outcome) or the other skeletal sites of interest. Truncal lean mass was significantly higher in the protein group at 18 months (P = .048). C-terminal telopeptide (P = .0414), IGF-1 (P = .0054), and urinary urea (P < .001) were also higher in the protein group at the end of the study period. There was no difference in estimated glomerular filtration rate at 18 months.

conclusionOur data suggest that protein supplementation above the recommended dietary allowance (0.8 g/kg) may preserve fat-free mass without adversely affecting skeletal health or renal function in healthy older adults.

Indexed as

AgedAged, 80 and overAgingBody CompositionBone and BonesBone DensityDietary ProteinsDietary SupplementsDouble-Blind MethodFemaleHumansMaleMiddle AgedMilk ProteinsOrgan SizeWhey ProteinsDietary ProteinsMilk ProteinsWhey Proteins

Identifiers

PMID25844619
PMCPMC4454800
OpenAlexW2022188251

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.