ArticlePhysiological reports2015
Reduced skeletal muscle oxidative capacity and impaired training adaptations in heart failure.
Article in Physiological reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- The Effects of Exercise Training on Mitochondrial Function in Cardiovascular Diseases: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2022Pooled it
- Vascular and skeletal muscle oxidative capacity responses to continuous double and single leg cycling.Experimental physiology · 2026Article
- Measuring Muscle Post-Exercise Oxygen Consumption in Individuals with a Family History of Diabetes.Journal of functional morphology and kinesiology · 2026Article
- Association of skeletal muscle oxidative capacity with muscle function, sarcopenia-related exercise performance, and intramuscular adipose tissue in older adults.GeroScience · 2024Article
- Effects of Particulate Matter Inhalation during Exercise on Oxidative Stress and Mitochondrial Function in Mouse Skeletal Muscle.Antioxidants (Basel, Switzerland) · 2024Article
- Operational Modal Analysis of Near-Infrared Spectroscopy Measure of 2-Month Exercise Intervention Effects in Sedentary Older Adults with Diabetes and Cognitive Impairment.Brain sciences · 2023Article
- Microvascular and oxidative stress responses to acute high-altitude exposure in prematurely born adults.Scientific reports · 2023Article
- Cardiovascular Mechanisms of Exercise Intolerance in Older Patients with Heart Failure.Reviews in cardiovascular medicine · 2022Review
- Article
- Mechanism of Dyspnea during Exercise in Children with Corrected Congenital Heart Disease.International journal of environmental research and public health · 2021Article
- Non-invasively measured central and peripheral factors of oxygen uptake differ between patients with chronic heart failure and healthy controls.BMC cardiovascular disorders · 2020Article
- High-fat diet affects skeletal muscle mitochondria comparable to pressure overload-induced heart failure.Journal of cellular and molecular medicine · 2020Article
- Impaired skeletal muscle performance as a consequence of random functional capillary rarefaction can be restored with overload-dependent angiogenesis.The Journal of physiology · 2020Article
- Review of early development of near-infrared spectroscopy and recent advancement of studies on muscle oxygenation and oxidative metabolism.The journal of physiological sciences : JPS · 2019Review
- Regional Differences in Mitochondrial Capacity in the Finger Flexors of Piano Players.Journal of functional morphology and kinesiology · 2019Article
- Skeletal Muscle Neurovascular Coupling, Oxidative Capacity, and Microvascular Function with 'One Stop Shop' Near-infrared Spectroscopy.Journal of visualized experiments : JoVE · 2018Article
- Near-infrared spectroscopy detects age-related differences in skeletal muscle oxidative function: promising implications for geroscience.Physiological reports · 2018Article
- Enhanced Local Skeletal Muscle Oxidative Capacity and Microvascular Blood Flow Following 7-Day Ischemic Preconditioning in Healthy Humans.Frontiers in physiology · 2018Article
- Endurance neuromuscular electrical stimulation training improves skeletal muscle oxidative capacity in individuals with motor-complete spinal cord injury.Muscle & nerve · 2017 · on this mapArticle
- Skeletal muscle bioenergetics in aging and heart failure.Heart failure reviews · 2017Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Systolic heart failure (HF) is associated with exercise intolerance that has been attributed, in part, to skeletal muscle dysfunction. The purpose of this study was to compare skeletal muscle oxidative capacity and training-induced changes in oxidative capacity in participants with and without HF. Participants with HF (n = 16, 65 ± 6.6 years) were compared with control participants without HF (n = 23, 61 ± 5.0 years). A subset of participants (HF: n = 7, controls: n = 5) performed 4 weeks of wrist-flexor exercise training. Skeletal muscle oxidative capacity was determined from the recovery kinetics of muscle oxygen consumption measured by near-infrared spectroscopy (NIRS) following a brief bout of wrist-flexor exercise. Oxidative capacity, prior to exercise training, was significantly lower in the HF participants in both the dominant (1.31 ± 0.30 min(-1) vs. 1.59 ± 0.25 min(-1), P = 0.002; HF and control groups, respectively) and nondominant arms (1.29 ± 0.24 min(-1) vs. 1.46 ± 0.23 min(-1), P = 0.04; HF and control groups, respectively). Following 4 weeks of endurance training, there was a significant difference in the training response between HF and controls, as the difference in oxidative training adaptations was 0.69 ± 0.12 min(-1) (P < 0.001, 95% CI 0.43, 0.96). The wrist-flexor training induced a ~50% improvement in oxidative capacity in participants without HF (mean difference from baseline = 0.66 ± 0.09 min(-1), P < 0.001, 95% CI 0.33, 0.98), whereas participants with HF showed no improvement in oxidative capacity (mean difference from baseline = -0.04 ± 0.08 min(-1), P = 0.66, 95% CI -0.24, 0.31), suggesting impairments in mitochondrial biogenesis. In conclusion, participants with HF had reduced oxidative capacity and impaired oxidative adaptations to endurance exercise compared to controls.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.