Evidence map›Paper›PMID 25856751›Full record

ArticleCell host & microbe2015

The multidimensional nature of antiviral innate immunity.

Reuben S Harris, Fred W Perrino, Nadine M Shaban

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Reuben S HarrisDepartment of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, and Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: rsh@umn.edu.
Fred W PerrinoDepartment of Biochemistry, Center for Structural Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Nadine M ShabanDepartment of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, and Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

Funding

Structural Characterization of APOBECS's Atomic interactionsP01GM091743 · NIGMS · UNIVERSITY OF MINNESOTA · PI HARRIS, REUBEN S · 2011 to 2015
$10.1M
APOBEC3 Proteins in HIV RestrictionR37AI064046 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HARRIS, REUBEN S · 2015 to 2024
$4.2M
APOBEC proteins and uracil in retrovirus restrictionR01AI064046 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HARRIS, REUBEN S · 2005 to 2014
$3.0M
Cellular Nucleotide Metabolism in HIV RestrictionR01GM110734 · NIGMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI PERRINO, FRED W · 2014 to 2017
$1.5M
NIAID NIH HHS R01 AI064046NIAID NIH HHS R37 AI064046NIGMS NIH HHS P01 GM091743NIGMS NIH HHS R01 GM110734
6 · The paper itself

Abstract

Viruses possess elaborate defensive mechanisms to evade host innate immune responses. In this issue of Cell Host & Microbe, Stavrou et al. (2015) reveal how the murine leukemia virus uses a sugar-protein shield to protect from inevitable destruction by cellular innate immune factors including the APOBEC3 DNA mutating enzyme.

Indexed as

AnimalsCytidine DeaminaseDNA, ViralInterferon-betaLeukemia Virus, MurineMacrophagesCytidine DeaminaseDNA, ViralInterferon-beta

Identifiers

PMID25856751
PMCPMC4616157

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.