ArticleNature communications2015
Dynamic imaging of the growth plate cartilage reveals multiple contributors to skeletal morphogenesis.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Unconventional auricular reconstruction using controlled scaffold buckling and chondrogenic cocktail containing muscle-derived cells.Bioactive materials · 2026Article
- Fibroblast Growth Factor 19 Disrupts Cartilage Development Via the FGFR4/β-catenin Axis.International journal of biological sciences · 2025Article
- Quantifying mechanical forces during vertebrate morphogenesis.Nature materials · 2024Article
- Article
- Depletion of b-series ganglioside prevents limb length discrepancy after growth plate injury.BMC musculoskeletal disorders · 2024Article
- α-parvin controls chondrocyte column formation and regulates long bone development.Bone research · 2023Article
- Lineage-specific accelerated sequences underlying primate evolution.Science advances · 2023Article
- Resolving morphogenesis into quantifiable cell behaviours.Development (Cambridge, England) · 2022Article
- Insights into skeletal stem cells.Bone research · 2022Review
- Application of 3D MAPs pipeline identifies the morphological sequence chondrocytes undergo and the regulatory role of GDF5 in this process.Nature communications · 2021Article
- Premature Growth Plate Closure Caused by a Hedgehog Cancer Drug Is Preventable by Co-Administration of a Retinoid Antagonist in Mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Article
- Clonal analysis and dynamic imaging identify multipotency of individual Gallus gallus caudal hindbrain neural crest cells toward cardiac and enteric fates.Nature communications · 2021Article
- Making and shaping endochondral and intramembranous bones.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Review
- Macropinocytosis-mediated membrane recycling drives neural crest migration by delivering F-actin to the lamellipodium.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- In Vitro Study of Extracellular Vesicles Migration in Cartilage-Derived Osteoarthritis Samples Using Real-Time Quantitative Multimodal Nonlinear Optics Imaging.Pharmaceutics · 2020Article
- Review
- Home for a rest: stem cell niche of the postnatal growth plate.The Journal of endocrinology · 2020Review
- Differences in Cell Proliferation and Craniofacial Phenotype of Closely Related Species in the Pupfish Genus Cyprinodon.The Journal of heredity · 2020Article
- Multiplex clonal analysis in the chick embryo using retrovirally-mediated combinatorial labeling.Developmental biology · 2019Article
- Possible Contribution of Wnt-Responsive Chondroprogenitors to the Postnatal Murine Growth Plate.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The diverse morphology of vertebrate skeletal system is genetically controlled, yet the means by which cells shape the skeleton remains to be fully illuminated. Here we perform quantitative analyses of cell behaviours in the growth plate cartilage, the template for long bone formation, to gain insights into this process. Using a robust avian embryonic organ culture, we employ time-lapse two-photon laser scanning microscopy to observe proliferative cells' behaviours during cartilage growth, resulting in cellular trajectories with a spreading displacement mainly along the tissue elongation axis. We build a novel software toolkit of quantitative methods to segregate the contributions of various cellular processes to the cellular trajectories. We find that convergent-extension, mitotic cell division, and daughter cell rearrangement do not contribute significantly to the observed growth process; instead, extracellular matrix deposition and cell volume enlargement are the key contributors to embryonic cartilage elongation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.