ArticleJournal of neurophysiology2015
Remote limb ischemic conditioning enhances motor learning in healthy humans.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04598711 (Effects of Remote Limb Ischemic Conditioning to Enhance Muscle Power, Dynamic Balance, and Walking Performance in Children With Cerebral Palsy), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Remote Limb Ischemic Conditioning to Enhance Muscle Power, Dynamic Balance, and Walking Performance in Children With Cerebral Palsy
Who cites it
21 citing papers in PubMed.
- Effects of ischemic conditioning on microvascular reactivity to single passive limb movement in young adults: a pilot study.European journal of applied physiology · 2025Trial
- Effects of remote limb ischemic conditioning on muscle strength in healthy young adults: A randomized controlled trial.PloS one · 2020Trial
- Remote Limb Ischemic Conditioning and Motor Learning: Evaluation of Factors Influencing Response in Older Adults.Translational stroke research · 2019Trial
- Dose of remote limb ischemic conditioning for enhancing learning in healthy young adults.Experimental brain research · 2019Trial
- Two weeks of ischemic conditioning improves walking speed and reduces neuromuscular fatigability in chronic stroke survivors.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Trial
- Ischemic conditioning increases strength and volitional activation of paretic muscle in chronic stroke: a pilot study.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Trial
- Effects of 4 weeks of low-load unilateral resistance training, with and without blood flow restriction, on strength, thickness, V wave, and H reflex of the soleus muscle in men.European journal of applied physiology · 2017Trial
- No influence of ischemic preconditioning on running economy.European journal of applied physiology · 2017Trial
- Remote Limb Ischemic Conditioning at Two Cuff Inflation Pressures Yields Learning Enhancements in Healthy Adults.Journal of motor behaviorTrial
- Feasibility, Safety, and Tolerability of Remote Ischemic Conditioning in Children with Unilateral Cerebral Palsy: A Randomized Controlled Trial.Children (Basel, Switzerland) · 2025Article
- Blood flow modulation to improve motor and neurophysiological outcomes in individuals with stroke: a scoping review.Experimental brain research · 2024Article
- Article
- A review of remote ischemic conditioning as a potential strategy for neural repair poststroke.CNS neuroscience & therapeutics · 2023Review
- Effects of Remote Ischemic Conditioning on Hand Engagement in individuals with Spinal cord Injury (RICHES): protocol for a pilot crossover study.F1000Research · 2021Article
- Effects of Different Tissue Flossing Applications on Range of Motion, Maximum Voluntary Contraction, and H-Reflex in Young Martial Arts Fighters.Frontiers in physiology · 2021Article
- Sex differences in fatigability after ischemic preconditioning of non-exercising limbs.Biology of sex differences · 2020Article
- Modulation of spinal cord excitability following remote limb ischemic preconditioning in healthy young men.Experimental brain research · 2020Article
- Association of sickle cell trait with measures of cognitive function and dementia in African Americans.eNeurologicalSci · 2019Article
- Isometric Exercise Training for Managing Vascular Risk Factors in Mild Cognitive Impairment and Alzheimer's Disease.Frontiers in aging neuroscience · 2017Review
- Heterogeneity of B Cell Functions in Stroke-Related Risk, Prevention, Injury, and Repair.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brief bouts of sublethal ischemia have been shown to protect exposed tissue (ischemic conditioning) and tissues at remote sites (remote ischemic conditioning) against subsequent ischemic challenges. Given that the mechanisms of this protective phenomenon are multifactorial and epigenetic, we postulated that remote limb ischemic conditioning (RLIC) might enhance mechanisms responsible for neural plasticity, and thereby facilitate learning. Specifically, we hypothesized that conditioning of the nervous system with RLIC, achieved through brief repetitive limb ischemia prior to training, would facilitate the neurophysiological processes of learning, thus making training more effective and more long-lasting. Eighteen healthy adults participated in this study; nine were randomly allocated to RLIC and nine to sham conditioning. All subjects underwent seven consecutive weekday sessions and 2-wk and 4-wk follow-up sessions. We found that RLIC resulted in significantly greater motor learning and longer retention of motor performance gains in healthy adults. Changes in motor performance do not appear to be due to a generalized increase in muscle activation or muscle strength and were not associated with changes in serum brain-derived neurotrophic factor (BDNF) concentration. Of note, RLIC did not enhance cognitive learning on a hippocampus-dependent task. While future research is needed to establish optimal conditioning and training parameters, this inexpensive, clinically feasible paradigm might ultimately be implemented to enhance motor learning in individuals undergoing neuromuscular rehabilitation for brain injury and other pathological conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.