Evidence map›Paper›PMID 25876740›Full record

Trial reportJournal of general internal medicine2015

Does Type 2 Diabetes Genetic Testing and Counseling Reduce Modifiable Risk Factors? A Randomized Controlled Trial of Veterans.

Corrine I Voils, Cynthia J Coffman, Janet M Grubber, David Edelman, Azita Sadeghpour, Matthew L Maciejewski, Jamiyla Bolton, Alex Cho, Geoffrey S Ginsburg, William S Yancy

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of general internal medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
5.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01060540 nacompletednot on this map

The Impact of Genetic Testing for Type 2 Diabetes on Health Behaviors

TypeinterventionalSponsorUS Department of Veterans AffairsRan2010 to 2013Enrolled601ConditionsDiabetes MellitusArmsgenetic testing for type 2 diabetes, Conventional risk counseling, eye disease counseling
NCT04331535 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Pragmatic Randomized Trial of Polygenic Risk Scoring for Common Diseases in Primary Care

TypeinterventionalSponsorBoston VA Research Institute, Inc.Ran2020 to 2025Enrolled1,076ConditionsCoronary Artery Disease, Atrial Fibrillation, Type 2 Diabetes, Colorectal CancerArmsPolygenic risk score (PRS)
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Corrine I VoilsCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, 508 Fulton St., Durham, NC, 27705, USA. corrine.voils@dm.duke.edu.
Cynthia J CoffmanCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, 508 Fulton St., Durham, NC, 27705, USA. cynthia.coffman@duke.edu.
Janet M GrubberCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, 508 Fulton St., Durham, NC, 27705, USA. janet.grubber@va.gov.
David EdelmanCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, 508 Fulton St., Durham, NC, 27705, USA. dedelman@duke.edu.
Azita SadeghpourDepartment of Medicine, Duke University Medical Center, Campus Box 3709, Durham, NC, 27710, USA. azita.sadeghpour@duke.edu.
Matthew L MaciejewskiCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, 508 Fulton St., Durham, NC, 27705, USA. matthew.maciejewski@va.gov.
Jamiyla BoltonCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, 508 Fulton St., Durham, NC, 27705, USA. jamiyla.bolton@va.gov.
Alex ChoDepartment of Medicine, Duke University Medical Center, 3100 Tower Blvd, Suite 600, DUMC Box 3329, Durham, NC, 27707, USA. alex.cho@duke.edu.
Geoffrey S GinsburgDepartment of Medicine, Duke University Medical Center, Durham, NC, 27710, USA. geoffrey.ginsburg@duke.edu.
William S YancyCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, 508 Fulton St., Durham, NC, 27705, USA. yancy006@mc.duke.edu.
Durham VA Medical Center · USDuke Medical Center · USDuke University Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe examined the clinical utility of supplementing type 2 diabetes mellitus (DM) risk counseling with DM genetic test results and counseling. RESEARCH DESIGN AND

methodsIn this randomized controlled trial, non-diabetic overweight/obese veteran outpatients aged 21 to 65 years received DM risk estimates for lifetime risk, family history, and fasting plasma glucose, followed by either genetic test results (CR+G; N = 303) or control eye disease counseling (CR+EYE; N = 298). All participants received brief lifestyle counseling encouraging weight loss to reduce the risk of DM.

resultsThe mean age was 54 years, 53% of participants were black, and 80% were men. There was no difference between arms in weight (estimated mean difference between CR+G vs. CR+EYE at 3 months = 0.2 kg, 95% CI: -0.3 to 0.7; at 6 months = 0.4 kg, 95 % CI: -0.3 to 1.1), insulin resistance, perceived risk, or physical activity at 3 or 6 months. Calorie and fat intake were lower in the CR+G arm at 3 months (p's ≤ 0.05) but not at 6 months (p's > 0.20).

conclusionsProviding patients with genetic test results was not more effective in changing patient behavior to reduce the risk of DM compared to conventional risk counseling.

trial registrationClinicalTrials.gov NCT01060540 http://clinicaltrials.gov/show/NCT01060540.

Indexed as

AdultAgedCounselingDiabetes Mellitus, Type 2FemaleGenetic CounselingGenetic Predisposition to DiseaseGenetic TestingHealth BehaviorHumansLife StyleMaleMiddle AgedNorth CarolinaObesityOutcome Assessment, Health CareDiabetes mellitusGenetic counselingRisk factors

Identifiers

PMID25876740
PMCPMC4617940
OpenAlexW2075059741

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.