Observational studyPloS one2015
Association of individual non-steroidal anti-inflammatory drugs and chronic kidney disease: a population-based case control study.
Observational study in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Prevalence of chronic kidney disease stages 3-5 in low- and middle-income countries in Asia: A systematic review and meta-analysis.PloS one · 2022Pooled it
- Relationship Between Intraarticular Injections on Patient-reported Outcomes in Total Knee Arthroplasty.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026Article
- The Present and Future of Pain Management in Patients With Chronic Kidney Disease: A Narrative Review.Cureus · 2025Review
- Renal safety of Long-Term Non-steroidal Anti-inflammatory drugs use in patients with ankylosing spondylitis.Scientific reports · 2025Article
- Health-Related Quality of Life in Patients End-Stage Kidney Disease with Hypertension: Hemodialysis Vs Continuous Ambulatory Peritoneal Dialysis Using EQ-5D-5L at a Tertiary Center in Indonesia.International journal of nephrology and renovascular disease · 2025Article
- Ketorolac Dose Ceiling Effect for Pediatric Headache in the Emergency Department.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2024Article
- Real-world patient characteristics and use of disease-modifying anti-rheumatic drugs in patients with rheumatoid arthritis: a cross-national study.Clinical rheumatology · 2023Article
- Non-steroidal anti-inflammatory drugs in chronic kidney disease and risk of acute adverse kidney events according to route of administration.International urology and nephrology · 2023Article
- Non-traditional risk factors of progression of chronic kidney disease in adult population: a scoping review.Frontiers in medicine · 2023Article
- Bartter Syndrome: Perspectives of a Pediatric Nephrologist.Electrolyte & blood pressure : E & BP · 2022Review
- Glomerular filtration rate abnormalities in sickle cell disease.Frontiers in medicine · 2022Review
- Burden of Renal Events Associated with Nonsteroidal Anti-inflammatory Drugs in Patients with Osteoarthritis and Chronic Low Back Pain: A Retrospective Database Study.Pain and therapy · 2021Article
- Perioperative Nonsteroidal Anti-Inflammatory Agents in the COVID-19 Orthopedic Patient.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2020Review
- Chronic Kidney Disease Management in General Practice: A Focus on Inappropriate Drugs Prescriptions.Journal of clinical medicine · 2020Article
- Long-term Assessment of NSAID Prescriptions and Potential Nephrotoxicity Risk in Adult Kidney Transplant Recipients.Transplantation · 2019Article
- [Treatment of rheumatic disease with renal insufficiency].Der Orthopade · 2019Review
- A novel CLCNKB mutation in a Chinese girl with classic Bartter syndrome: a case report.BMC medical genetics · 2019Article
- Characterization and preventability of adverse drug events as cause of emergency department visits: a prospective 1-year observational study.BMC pharmacology & toxicology · 2019Observational
- Article
- Clinical and diagnostic features of Bartter and Gitelman syndromes.Clinical kidney journal · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-steroidal anti-inflammatory agents (NSAIDs) are known to be associated with renal damage. No clear evidence exists regarding differential risk of chronic kidney disease (CKD), specifically, across various NSAIDs.
aimThe aim of this population-based case-control study was to evaluate the association between use of individual NSAIDs and risk of CKD in a general population of Southern Italy.
methodsA nested case-control study was carried out using the general practice Arianna database, identifying incident CKD patients as cases and matched controls from 2006 to 2011. The date of first CKD diagnosis was defined as the index date (ID). Conditional logistic regressions were performed to estimate the risk of CKD associated with NSAIDs by class and individual drugs as compared to non-use during different time windows (within one year, six or three months prior to ID), with the latter being defined as current users. Among current users, the effect of cumulative exposure to these drugs was evaluated.
resultsOverall, 1,989 CKD cases and 7,906 matched controls were identified. A statistically significant increase in the risk of CKD was found for current users of oxicams (adjusted OR: 1.68; 95% CI: 1.15-2.44) and concerning individual compounds, for ketorolac (adj. OR: 2.54; 95% CI: 1.45-4.44), meloxicam (adj. OR: 1.98; 95% CI: 1.01-3.87) and piroxicam (adj. OR: 1.95; 95% CI: 1.19-3.21).
conclusionsThe risk of CKD varies across individual NSAIDs. Increased risk has been found for ketorolac, which may precipitate subclinical CKD through acute renal damage, and long-term exposure to oxicams, especially meloxicam and piroxicam.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.