Developing medicines that mimic the natural successes of the human genome: lessons from NPC1L1, HMGCR, PCSK9, APOC3, and CETP.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

1. Using human induced pluripotent stem cell-derived cardiomyocytes to understand the mechanisms driving cardiomyocyte maturation.Frontiers in cardiovascular medicine · 2022
   Pooled it
2. Association Between Low-Density Lipoprotein Cholesterol-Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis.JAMA · 2016 · on this map
   Pooled it
3. Targeted Treatment of Individuals With Psychosis Carrying a Copy Number Variant Containing a Genomic Triplication of the Glycine Decarboxylase Gene.Biological psychiatry · 2019
   Trial
4. Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye.JAMA · 2021
   Observational
5. Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits.BMC medical genomics · 2019
   Article
6. The genetics of depression: successful genome-wide association studies introduce new challenges.Translational psychiatry · 2019
   Article
7. Psychiatric genetics and the structure of psychopathology.Molecular psychiatry · 2019
   Review
8. Indications of PCSK9 Inhibitors for Patients at High and Very High Cardiovascular Risk.Arquivos brasileiros de cardiologia · 2018
   Review
9. Human gene essentiality.Nature reviews. Genetics · 2018
   Review
10. A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels.Nature medicine · 2017
    Article
11. APOC3 induces endothelial dysfunction through TNF-α and JAM-1.Lipids in health and disease · 2016
    Article
12. Analysis of protein-coding genetic variation in 60,706 humans.Nature · 2016
    Article
13. GPIHBP1 and Plasma Triglyceride Metabolism.Trends in endocrinology and metabolism: TEM · 2016
    Review
14. Harnessing publicly available genetic data to prioritize lipid modifying therapeutic targets for prevention of coronary heart disease based on dysglycemic risk.Human genetics · 2016
    Article
15. The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016
    Review

Corrections and comments

• Comment on
  Effect of naturally random allocation to lower low-density lipoprotein cholesterol on the risk of coronary heart disease mediated by polymorphisms in NPC1L1, HMGCR, or both: a 2 × 2 factorial Mendelian randomization study.2015

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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