Evidence map›Paper›PMID 25884482›Full record

Observational studyReproductive biology and endocrinology : RB&E2015

Menstrual cycle length: a surrogate measure of reproductive health capable of improving the accuracy of biochemical/sonographical ovarian reserve test in estimating the reproductive chances of women referred to ART.

Salvatore Gizzo, Alessandra Andrisani, Marco Noventa, Michela Quaranta, Federica Esposito, Decio Armanini, Michele Gangemi, Giovanni B Nardelli, Pietro Litta, Donato D'Antona and 1 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Reproductive biology and endocrinology : RB&E, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Trial
  5. Observational
  6. Article
  7. Systemic inflammation and menstrual cycle length in a prospective cohort study.American journal of obstetrics and gynecology · 2023
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  8. Article
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  11. MOTHER Study: AJournal of obstetrics and gynaecology of India · 2021
    Article
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  13. Ovarian Reserve Biomarkers and Menstrual Cycle Length in a Prospective Cohort Study.The Journal of clinical endocrinology and metabolism · 2021
    Article
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Salvatore GizzoDepartment of Woman and Child Health, University of Padua, Gynecologic and Obstetric Clinic, Giustiniani 3 street, 35128, Padua, Italy. ginecologia_padova@libero.it.
Alessandra AndrisaniDepartment of Woman and Child Health, University of Padua, Gynecologic and Obstetric Clinic, Giustiniani 3 street, 35128, Padua, Italy. alessandra.andrisani@unipd.it.
Marco NoventaDepartment of Woman and Child Health, University of Padua, Gynecologic and Obstetric Clinic, Giustiniani 3 street, 35128, Padua, Italy. marco.noventa@gmail.com.
Michela QuarantaDepartment of Obstetrics and Gynaecology, University of Verona, Piazzale Ludovico Scuro 10 street, 37134, Verona, Italy. michela40mq@gmail.com.
Federica EspositoDepartment of Woman and Child Health, University of Padua, Gynecologic and Obstetric Clinic, Giustiniani 3 street, 35128, Padua, Italy. fede.esp@hotmail.it.
Decio ArmaniniDepartment of Medicine-Endocrinology, University of Padua, Giustiniani 2 street, 35128, Padua, Italy. decio.armanini@unipd.it.
Michele GangemiDepartment of Woman and Child Health, University of Padua, Gynecologic and Obstetric Clinic, Giustiniani 3 street, 35128, Padua, Italy. michele.gangemi@unipd.it.
Giovanni B NardelliDepartment of Woman and Child Health, University of Padua, Gynecologic and Obstetric Clinic, Giustiniani 3 street, 35128, Padua, Italy. giovannibattista.nardelli@unipd.it.
Pietro LittaDepartment of Woman and Child Health, University of Padua, Gynecologic and Obstetric Clinic, Giustiniani 3 street, 35128, Padua, Italy. pietro.litta@unipd.it.
Donato D'AntonaDepartment of Woman and Child Health, University of Padua, Gynecologic and Obstetric Clinic, Giustiniani 3 street, 35128, Padua, Italy. donato.dantona@unipd.it.
Guido AmbrosiniDepartment of Woman and Child Health, University of Padua, Gynecologic and Obstetric Clinic, Giustiniani 3 street, 35128, Padua, Italy. guido.ambrosini@unipd.it.
University of Padua · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAim of the study was to investigate whether menstrual cycle length may be considered as a surrogate measure of reproductive health, improving the accuracy of biochemical/sonographical ovarian reserve test in estimating the reproductive chances of women referred to ART.

methodsA retrospective-observational-study in Padua' public tertiary level Centre was conducted. A total of 455 normo-ovulatory infertile women scheduled for their first fresh non-donor IVF/ICSI treatment. The mean menstrual cycle length (MCL) during the preceding 6 months was calculated by physicians on the basis of information contained in our electronic database (first day of menstrual cycle collected every month by telephonic communication by single patients). We evaluated the relations between MCL, ovarian response to stimulation protocol, oocytes fertilization ratio, ovarian sensitivity index (OSI) and pregnancy rate in different cohorts of patients according to the class of age and the estimated ovarian reserve.

resultsIn women younger than 35 years, MCL over 31 days may be associated with an increased risk of OHSS and with a good OSI. In women older than 35 years, and particularly than 40 years, MCL shortening may be considered as a marker of ovarian aging and may be associated with poor ovarian response, low OSI and reduced fertilization rate. When AMH serum value is lower than 1.1 ng/ml in patients older than 40 years, MCL may help Clinicians discriminate real from expected poor responders. Considering the pool of normoresponders, MCL was not correlated with pregnancy rate while a positive association was found with patients' age.

conclusionsMCL diary is more predictive than chronological age in estimating ovarian biological age and response to COH and it is more predictive than AMH in discriminating expected from real poor responders. In women older than 35 years MCL shortening may be considered as a marker of ovarian aging while chronological age remains most accurate parameter in predicting pregnancy.

Indexed as

Ovarian ReserveReproductive HealthAdultAge FactorsAnti-Mullerian HormoneFemaleHumansInfertility, FemaleMenstrual CycleMiddle AgedOvarian Hyperstimulation SyndromeOvaryOvulation InductionPregnancyPregnancy RateReproductive Techniques, AssistedAnti-Mullerian Hormone

Identifiers

PMID25884482
PMCPMC4396168
OpenAlexW2168484362

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.