ArticleEuropean radiology2015
Aberrant functional connectivity of default-mode network in type 2 diabetes patients.
Article in European radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 7 of them syntheses that pooled it.
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Who cites it
77 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Structural and functional brain abnormal alteration in patients with type 2 diabetes mellitus: A coordinate-based meta-analysis.Translational psychiatry · 2025Pooled it
- The Impact of Exercise Training on the Brain and Cognition in Type 2 Diabetes, and its Physiological Mediators: A Systematic Review.Sports medicine - open · 2025Pooled it
- Changes of brain function in patients with type 2 diabetes mellitus measured by different analysis methods: A new coordinate-based meta-analysis of neuroimaging.Frontiers in neurology · 2022Pooled it
- Gray Matter Abnormalities in Type 1 and Type 2 Diabetes: A Dual Disorder ALE Quantification.Frontiers in neuroscience · 2021Pooled it
- Regional Spontaneous Neural Activity Alterations in Type 2 Diabetes Mellitus: A Meta-Analysis of Resting-State Functional MRI Studies.Frontiers in aging neuroscience · 2021Pooled it
- Abnormalities of Brain White Matter in Type 2 Diabetes Mellitus: A Meta-Analysis of Diffusion Tensor Imaging.Frontiers in aging neuroscience · 2021Pooled it
- Altered functional connectivity of brain regions based on a meta-analysis in patients with T2DM: A resting-state fMRI study.Brain and behavior · 2020Pooled it
- Resting-state BOLD-CBF coupling in end-stage renal disease with diabetic kidney disease patients: associations with clinical characteristics and cognitive function.Brain imaging and behavior · 2026Article
- From Metabolism to Mind: The Cardio-Metabolic-Brain Axis and the Role of Insulin Resistance-A Review.Biomedicines · 2026Review
- Functional brain network connectivity patterns associated with midlife metabolic syndrome and cognitive vulnerabilities.Frontiers in aging neuroscience · 2026Article
- Altered static and dynamic functional network connectivity between subcortical nuclei and cortical regions of the default mode network in type 2 diabetes mellitus.Frontiers in neuroscience · 2026Article
- Review
- Transcranial Direct Current Stimulation (tDCS) in Diabetes: A Focused and Mechanistic Review of Symptom and Function Outcomes.Journal of clinical medicine · 2025Review
- The Energetic Collapse of the Alzheimer's Brain: Metabolic Inflexibility Across Cells and Networks.Journal of neurochemistry · 2025Review
- Improvement in Insulin Sensitivity Prevents Decline in Glucose Uptake, Functional Connectivity, and Volume in the Insulin Resistant Human Brain.Research square · 2025Article
- Schisandrin A ameliorates the diabetes-associated memory impairment by alleviating inflammation and ferroptosis.Acta biochimica et biophysica Sinica · 2025Article
- Sleep habits, brain functional networks, and type 2 diabetes risk: cohort studies from North American and Asian populations and mediating Mendelian randomization analyses.Diabetology & metabolic syndrome · 2025Article
- A systematic review of in vivo brain insulin resistance biomarkers in humans.Biomarkers in neuropsychiatry · 2025Review
- Altered brain function and structure in youth-onset type 2 diabetes.European journal of endocrinology · 2025Article
- Causal Central Network Remodeling in Diabetic Neuropathy: An Integrated MR-fMRI Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesType 2 diabetes mellitus is associated with increased risk for dementia. Patients with impaired cognition often show default-mode network disruption. We aimed to investigate the integrity of a default-mode network in diabetic patients by using independent component analysis, and to explore the relationship between network abnormalities, neurocognitive performance and diabetic variables.
methodsForty-two patients with type 2 diabetes and 42 well-matched healthy controls were included and underwent resting-state functional MRI in a 3 Tesla unit. Independent component analysis was adopted to extract the default-mode network, including its anterior and posterior components. Z-maps of both sub-networks were compared between the two groups and correlated with each clinical variable.
resultsPatients showed increased connectivity around the medial prefrontal cortex in the anterior sub-network, but decreased connectivity around the posterior cingulate cortex in the posterior sub-network. The decreased connectivity in the posterior part was significantly correlated with the score on Complex Figure Test-delay recall test (r = 0.359, p = 0.020), the time spent on Trail-Making Test-part B (r = -0.346, p = 0.025) and the insulin resistance level (r = -0.404, p = 0.024).
conclusionDissociation pattern in the default-mode network was found in diabetic patients, which might provide powerful new insights into the neural mechanisms that underlie the diabetes-related cognitive decline. KEY POINTS: • Type 2 diabetes mellitus is associated with impaired cognition • Default- mode network plays a central role in maintaining normal cognition • Network connectivity within the default mode was disrupted in type 2 diabetes patients • Decreased network connectivity was correlated with cognitive performance and insulin resistance level • Disrupted default-mode network might explain the impaired cognition in diabetic population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.