Evidence map›Paper›PMID 25912168›Full record

ReviewRedox biology2015

Oxygen in human health from life to death--An approach to teaching redox biology and signaling to graduate and medical students.

Margaret M Briehl

Open access · goldAbstract readReview
In one paragraph

Review in Redox biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Margaret M BriehlDepartment of Pathology, University of Arizona, PO Box 24-5043, Tucson, AZ 85724-5043, USA. Electronic address: mmbriehl@pathology.arizona.edu.
University of Arizona · US

Funding

Uranium as an Environmental Risk Factor for Cancer Among the NavajoU54CA143924 · NCI · UNIVERSITY OF ARIZONA · PI Melissa Marie Herbst-Kralovetz, JUANITA L. MERCHANT · 2009 to 2026
$26.7M
Redox Control of Apoptosis SignalingR01CA071768 · NCI · UNIVERSITY OF ARIZONA · PI BRIEHL, MARGARET M · 2001 to 2009
$1.8M
REDOX CONTROL AND APOPTOSISR29CA071768 · NCI · UNIVERSITY OF ARIZONA · PI BRIEHL, MARGARET M · 1996 to 2000
$105k
NCI NIH HHS NIHR01CA71768NCI NIH HHS R01 CA071768NCI NIH HHS U54 CA143924NCI NIH HHS U54CA143924
6 · The paper itself

Abstract

In the absence of oxygen human life is measured in minutes. In the presence of oxygen, normal metabolism generates reactive species (ROS) that have the potential to cause cell injury contributing to human aging and disease. Between these extremes, organisms have developed means for sensing oxygen and ROS and regulating their cellular processes in response. Redox signaling contributes to the control of cell proliferation and death. Aberrant redox signaling underlies many human diseases. The attributes acquired by altered redox homeostasis in cancer cells illustrate this particularly well. This teaching review and the accompanying illustrations provide an introduction to redox biology and signaling aimed at instructors of graduate and medical students.

Indexed as

Signal TransductionAgingHumansMitochondriaNeoplasmsNeoplastic Stem CellsOxidation-ReductionOxygenReactive Oxygen SpeciesStudents, MedicalOxygenReactive Oxygen SpeciesApoptosisCancerHydrogen peroxideMitochondriaProliferationSuperoxide

Identifiers

PMID25912168
PMCPMC4412967
OpenAlexW1977058357

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.