Trial reportPloS one2015
Caloric restriction decreases orthostatic tolerance independently from 6° head-down bedrest.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Pooled it
- Effects of short-term hypercaloric nutrition on orthostatic tolerance in healthy individuals: a randomized controlled crossover study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Trial
- The search for the ultimate exercise countermeasure to preserve crew health and ensure mission success in long-duration spaceflight.Experimental physiology · 2025Review
- Behavioral adaptation in diet maintains nutrient composition in an isolated, confined, and extreme environment in Antarctica.Frontiers in nutrition · 2025Article
- Women in space: A review of known physiological adaptations and health perspectives.Experimental physiology · 2024Review
- Energy metabolism and syncope.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- The Potential of Calorie Restriction and Calorie Restriction Mimetics in Delaying Aging: Focus on Experimental Models.Nutrients · 2021Review
- The incidence of orthostatic intolerance after bariatric surgery.Obesity science & practice · 2020Article
- Clinical Prognostic Factors in Pediatric Patients With Orthostatic Intolerance.Global pediatric health · 2020Article
- Gut Microbiome and Space Travelers' Health: State of the Art and Possible Pro/Prebiotic Strategies for Long-Term Space Missions.Frontiers in physiology · 2020Review
- Pediatric Disorders of Orthostatic Intolerance.Pediatrics · 2018Review
- Falls and Fall-Prevention in Older Persons: Geriatrics Meets Spaceflight!Frontiers in physiology · 2017Review
- Caloric restriction diminishes the pressor response to static exercise.Extreme physiology & medicine · 2016Article
- Towards human exploration of space: The THESEUS review series on nutrition and metabolism research priorities.NPJ microgravity · 2016Review
- Prevalence of vasovagal syncope following bariatric surgery.Saudi journal of anaesthesiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Astronauts consume fewer calories during spaceflight and return to earth with an increased risk of orthostatic intolerance. Whether a caloric deficiency modifies orthostatic responses is not understood. Thus, we determined the effects of a hypocaloric diet (25% caloric restriction) during 6° head down bedrest (an analog of spaceflight) on autonomic neural control during lower body negative pressure (LBNP). Nine healthy young men completed a randomized crossover bedrest study, consisting of four (2 weeks each) interventions (normocaloric bedrest, normocaloric ambulatory, hypocaloric bedrest, hypocaloric ambulatory), each separated by 5 months. Muscle sympathetic nerve activity (MSNA) was recorded at baseline following normocaloric and hypocaloric interventions. Heart rate (HR) and arterial pressure were recorded before, during, and after 3 consecutive stages (7 min each) of LBNP (-15, -30, -45 mmHg). Caloric and posture effects during LBNP were compared using two-way ANOVA with repeated measures. There was a strong trend toward reduced basal MSNA following caloric restriction alone (normcaloric vs. hypocaloric: 22±3 vs. 14±4 burst/min, p = 0.06). Compared to the normocaloric ambulatory, both bedrest and caloric restriction were associated with lower systolic blood pressure during LBNP (p<0.01); however, HR responses were directionally opposite (i.e., increase with bedrest, decrease with caloric restriction). Survival analysis revealed a significant reduction in orthostatic tolerance following caloric restriction (normocaloric finishers: 12/16; hypocaloric finishers: 6/16; χ2, p = 0.03). Caloric restriction modifies autonomic responses to LBNP, which may decrease orthostatic tolerance after spaceflight.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.