Evidence map›Paper›PMID 25927007›Full record

ArticleActa naturae

Selective Protective Potency of Yersinia pestis ΔnlpD Mutants.

S V Dentovskaya, S A Ivanov, P Kh Kopylov, R Z Shaikhutdinova, M E Platonov, T I Kombarova, T V Gapel'chenkova, S V Balakhonov, A P Anisimov

Open access · bronzeAbstract read
PubMed Full text at PMC
In one paragraph

Article in Acta naturae. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Biomolecules · 2020
    Review
  4. Review
  5. Host Iron Nutritional Immunity Induced by a LiveFrontiers in cellular and infection microbiology · 2017
    Article
  6. Plague Vaccines: Status and Future.Advances in experimental medicine and biology · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

S V DentovskayaState Research Center for Applied Microbiology, Obolensk, Moscow Region, 142279, Russia.
S A IvanovState Research Center for Applied Microbiology, Obolensk, Moscow Region, 142279, Russia.
P Kh KopylovState Research Center for Applied Microbiology, Obolensk, Moscow Region, 142279, Russia.
R Z ShaikhutdinovaState Research Center for Applied Microbiology, Obolensk, Moscow Region, 142279, Russia.
M E PlatonovState Research Center for Applied Microbiology, Obolensk, Moscow Region, 142279, Russia.
T I KombarovaState Research Center for Applied Microbiology, Obolensk, Moscow Region, 142279, Russia.
T V Gapel'chenkovaState Research Center for Applied Microbiology, Obolensk, Moscow Region, 142279, Russia.
S V BalakhonovIrkutsk Antiplague Research Institute of Siberia and Far East, Trilissera Str., 78, 664047, Irkutsk, Russia.
A P AnisimovState Research Center for Applied Microbiology, Obolensk, Moscow Region, 142279, Russia.
State Research Center for Applied Microbiology and Biotechnology · RUIrkutsk Antiplague Research Institute of Siberia and Far East · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has recently been shown that the NlpD lipoprotein is essential to Yersinia pestis virulence and that subcutaneous administration of the nlpD mutant could protect mice against bubonic and pneumonic plague better than the EV vaccine strain [PLoS One 2009. V. 4. № 9. e7023]. In this study, similar ΔnlpD mutants were generated on the basis of other Y. pestis parent strains, including strains from the subspecies microtus, which is avirulent to guinea pigs and humans. Comparative testing confirmed that immunization of mice with ΔnlpD mutants induces immunity 105 times more potent than the one induced by the administration of the EV vaccine strain. At the same time, NlpD- bacteria failed to protect guinea pigs in the case of a subcutaneous challenge with Y. pestis, inducing a 106 times less potent protection compared with that conferred by immunization with the EV vaccine strain. The possible causes of the observed phenomena are discussed.

Indexed as

live plague vaccineselectivity of protective potencyYersinia pestisΔnlpD mutant

Identifiers

PMID25927007
PMCPMC4410401
OpenAlexW1675108858

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.