Evidence map›Paper›PMID 25937196›Full record

ReviewJACC. Cardiovascular imaging2015

Coronary artery calcium scanning: past, present, and future.

Harvey S Hecht

2 registry-linked trialsAbstract readHistorical ArticleReview
PubMed Publisher
In one paragraph

Review in JACC. Cardiovascular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 140 papers.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed
24.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05998525 phase3completedstarted 2021, after this paper: background citation

Dapagliflozin Effects on Coronary Calcium and Epicardial Fat Assessed by Cardiotomography

Ran2021Enrolled54Registered outcomes6Posted comparisons0ConditionsDiabetes Mellitus, Type 2, Diabete Type 2, Myocardial Infarction, Unstable AnginaArmsDapagliflozin 10mg Tab, Placebo
Open the trial in the graph
NCT03548753 completednot on this mapstarted 2016, after this paper: background citation

Functional and Anatomical Testing in Intermediate Risk Chest Pain Patients With Severe Coronary Calcium Score

TypeobservationalSponsorOdense University HospitalRan2016 to 2018Enrolled278ConditionsObservational
3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 294 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. Sex-Specific Coronary Artery Calcium Score Threshold Predictive of Obstructive Coronary Artery Disease.Journal of the Society for Cardiovascular Angiography & Interventions · 2026
    Article
  12. A Framework for Cross-Domain Generalization in Coronary Artery Calcium Scoring Across Gated and Non-Gated Computed Tomography.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2026
    Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Updates on CAD risk assessment: using the coronary artery calcium score in combination with traditional risk factors.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025
    Review

80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Harvey S HechtIcahn School of Medicine at Mount Sinai, New York, New York. Electronic address: harvey.hecht@mountsinai.org.
Icahn School of Medicine at Mount Sinai · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronary artery calcium scanning (CAC) has emerged as the most robust predictor of coronary events in the asymptomatic primary prevention population, particularly in the intermediate-risk cohort. Every study has demonstrated its superiority to risk factor-based paradigms, e.g., the Framingham Risk Score, with outcome-based net reclassification indexes ranging from 52.0% to 65.6% in the intermediate-risk, 34.0% to 35.8% in the high-risk, and 11.6% to 15.0% in the low-risk cohorts. CAC improves medication and lifestyle adherence and is cost-effective in specified populations, with the ability to effectively stratify the number needed to treat and scan for different therapeutic strategies and patient cohorts. Data have emerged clearly demonstrating the worse prognosis associated with increasing CAC on serial scans, suggesting a potential role for evaluating residual risk and treatment success or failure. CAC is also strongly associated with the development of stroke and congestive heart failure.

Indexed as

Coronary AngiographyTomography, X-Ray ComputedCoronary Artery DiseaseCoronary VesselsDiffusion of InnovationForecastingHistory, 20th CenturyHistory, 21st CenturyHumansPredictive Value of TestsPrognosisRisk FactorsSeverity of Illness IndexVascular Calcificationatherosclerosiscoronary artery calciumprimary prevention

Identifiers

PMID25937196
OpenAlexW243886314

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.