Evidence map›Paper›PMID 25945500›Full record

Trial reportPloS one2015

Metformin versus Insulin in the Management of Pre-Gestational Diabetes Mellitus in Pregnancy and Gestational Diabetes Mellitus at the Korle Bu Teaching Hospital: A Randomized Clinical Trial.

Titus Beyuo, Samuel Amenyi Obed, Kenneth Kweku Adjepong-Yamoah, Kwasi Agyei Bugyei, Samuel Antwi Oppong, Kissinger Marfoh

Registry-linked trialOpen access · goldFull text readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06064669 (Effect of Metformin on Healthy Live Birth After In-vitro Fertilization in Women With Prediabetes Mellitus), which is not on this map. Cited by 22 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 6 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06064669 narecruitingstarted 2024, after this paper: background citation

Effect of Metformin on Healthy Live Birth After In-vitro Fertilization in Women With Prediabetes Mellitus: a Multicenter Double-blind Placebo Controlled Randomized Trial

Ran2024Enrolled988Registered outcomes26Posted comparisons0ConditionsIn-Vitro Fertilization, Metformin, PrediabetesArmsMetformin pretreatment before endometrial preparation for frozen embryo transfer, Metformin pretreatment before ovarian stimulation, Placebo pretreatment before endometrial preparation for frozen embryo transfer, Placebo pretreatment before ovarian stimulation
PMID 34281467PMID 29045765PMID 18826999PMID 11832527PMID 36396532PMID 36285403PMID 35151523PMID 34506996PMID 34461950PMID 34330423PMID 34182954PMID 33887240other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 6 syntheses or guidelines pooled it, 47 citations in OpenAlex.

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  5. Insulin for the treatment of women with gestational diabetes.The Cochrane database of systematic reviews · 2017
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  7. Effectiveness of Metformin in the Prevention of Gestational Diabetes Mellitus in Obese Pregnant Women.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Titus BeyuoDepartment of Obstetrics and Gynecology, Korle Bu Teaching Hospital, Accra, Ghana.
Samuel Amenyi ObedDepartment of Obstetrics and Gynecology, Korle Bu Teaching Hospital, Accra, Ghana.
Kenneth Kweku Adjepong-YamoahDepartment of Medicine and Therapeutics, Korle Bu Teaching Hospital and Department of Pharmacology, University of Ghana Medical School, Accra, Ghana.
Kwasi Agyei BugyeiDepartment of Pharmacology, University of Ghana Medical School, Accra, Ghana.
Samuel Antwi OppongDepartment of Obstetrics and Gynecology, Korle Bu Teaching Hospital, Accra, Ghana.
Kissinger MarfohPublic Health Unit, Korle Bu Teaching Hospital, Accra, Ghana.
Korle Bu Teaching Hospital · GHUniversity of Ghana · GH

Funding

FIC NIH HHS D43 TW009140
6 · The paper itself

Abstract

objectiveTo determine if metformin monotherapy or metformin in combination with insulin is equally effective as insulin monotherapy at glycemic control in diabetes mellitus in pregnancy among Ghanaians.

methodsThis was a study involving 104 pregnant women with type 2 diabetes mellitus (T2DM) or gestational diabetes mellitus (GDM) at 20-30 weeks gestation. Participants were randomized into metformin and insulin treatment groups. Starting dose of metformin was 500 mg once a day and increased gradually over two (2) weeks, to meet glycemic targets. Insulin was added if targets could not be reached on metformin alone at maximum doses. Total daily dose of premixed insulin at initiation was calculated as 0.3 IU/kg body weight and titrated upwards to achieve glycemic control. Glycemic profile monitoring was done every two weeks.

resultsThe two hour post prandial blood glucose (2HPG) levels were significantly lower in the metformin group than the insulin group (p= 0.004).

conclusionThe findings of this study suggest that metformin monotherapy is effective in achieving glycemic targets in the management of diabetes in pregnancy. It is more effective than insulin in lowering the 2HPG level.

trial registrationAustralian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12614000942651.

Indexed as

AdolescentAdultBlood GlucoseCost-Benefit AnalysisDiabetes, GestationalDiabetes Mellitus, Type 2Disease ManagementDrug Therapy, CombinationFemaleGhanaGlycemic IndexHospitals, TeachingHumansHypoglycemic AgentsInsulinMetforminBlood GlucoseHypoglycemic AgentsInsulinMetformin

Identifiers

PMID25945500
PMCPMC4422739
OpenAlexW1467934343

What Socratic holds

Textfull text, public
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.