Evidence map›Paper›PMID 25953426›Full record

ArticleActa orthopaedica2015

Diabetes is associated with persistent pain after hip and knee replacement.

Tuomas J Rajamäki, Esa Jämsen, Pia A Puolakka, Pasi I Nevalainen, Teemu Moilanen

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta orthopaedica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01743313 (Hyperglycemia in Joint Replacement Recipients), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01743313 terminatednot on this map

Hyperglycemia in Joint Replacement Recipients: Glucose Metabolism Disorders and Metabolic Syndrome in Osteoarthritis Patients Before and After Primary Hip and Knee Replacement

TypeobservationalSponsorCoxa, Hospital for Joint ReplacementRan2012 to 2017Enrolled155ConditionsHyperglycemia, Hypercholesterolemia, Persistent Postoperative Pain, Hip Replacement
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
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  10. Persistent pain following total knee arthroplasty: The role of underlying diseases.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023
    Article
  11. Elective hip arthroplasty rates and related complications in people with diabetes mellitus.Hip international : the journal of clinical and experimental research on hip pathology and therapy · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Tuomas J Rajamäkia 1School of Medicine, University of Tampere.
Esa Jämsenb 2 Coxa, Hospital for Joint Replacement.
Pia A Puolakkac 3 Department of Surgery and Anaesthesia.
Pasi I Nevalainena 1School of Medicine, University of Tampere.
Teemu Moilanenb 2 Coxa, Hospital for Joint Replacement.
Coxa Hospital · FIEuropean Society of Anaesthesiology · BETampere University · FITampere University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeIn some patients, for unknown reasons pain persists after joint replacement, especially in the knee. We determined the prevalence of persistent pain following primary hip or knee replacement and its association with disorders of glucose metabolism, metabolic syndrome (MetS), and obesity. PATIENTS AND

methodsThe incidence of pain in the operated joint was surveyed 1-2 years after primary hip replacement (74 patients (4 bilateral)) or primary knee replacement (119 patients (19 bilateral)) in 193 osteoarthritis patients who had participated in a prospective study on perioperative hyperglycemia. Of the 155 patients who completed the survey, 21 had undergone further joint replacement surgery during the follow-up and were excluded, leaving 134 patients for analysis. Persistent pain was defined as daily pain in the operated joint that had lasted over 3 months. Factors associated with persistent pain were evaluated using binary logistic regression with adjustment for age, sex, and operated joint.

results49 of the 134 patients (37%) had a painful joint and 18 of them (14%) had persistent pain. A greater proportion of knee patients than hip patients had a painful joint (46% vs. 24%; p = 0.01) and persistent pain (20% vs. 4%; p = 0.007). Previously diagnosed diabetes was strongly associated with persistent pain (5/19 vs. 13/115 in those without; adjusted OR = 8, 95% CI: 2-38) whereas MetS and obesity were not. However, severely obese patients (BMI ≥ 35) had a painful joint (but not persistent pain) more often than patients with BMI < 30 (14/21 vs. 18/71; adjusted OR = 5, 95% CI: 2-15).

interpretationPreviously diagnosed diabetes is a risk factor for persistent pain in the operated joint 1-2 years after primary hip or knee replacement.

Indexed as

AdultAgedAged, 80 and overArthralgiaArthroplasty, Replacement, HipArthroplasty, Replacement, KneeDiabetes MellitusFemaleHumansIncidenceLogistic ModelsMaleMiddle AgedOsteoarthritis, HipOsteoarthritis, KneePostoperative Complications

Identifiers

PMID25953426
PMCPMC4564781
OpenAlexW1800473427

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.