ArticleJournal of agricultural and food chemistry2015
Inhibition of Human Neutrophil Responses by the Essential Oil of Artemisia kotuchovii and Its Constituents.
Article in Journal of agricultural and food chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Estragole protects against ovalbumin-induced allergic asthma by amelioration of interleukin-4 and interleukin-5 expression in BALB/c mice.Journal of molecular histology · 2025Article
- Phytochemical Composition and Biological Activity of the Essential Oil fromPlants (Basel, Switzerland) · 2024Article
- Volatile Composition, Antimicrobial Activity, and In Vitro Innate Immunomodulatory Activity ofMolecules (Basel, Switzerland) · 2023Article
- How to Naturally Support the Immune System in Inflammation-Essential Oils as Immune Boosters.Biomedicines · 2023Review
- Composition and Biological Activity of the Essential Oils from Wild Horsemint, Yarrow, and Yampah from Subalpine Meadows in Southwestern Montana: Immunomodulatory Activity of Dillapiole.Plants (Basel, Switzerland) · 2023Article
- Advances in the Phytochemical Characterisation and Bioactivities ofPlants (Basel, Switzerland) · 2023Article
- Chemical Profile, Anti-Microbial and Anti-Inflammaging Activities ofAntibiotics (Basel, Switzerland) · 2023Article
- Neutrophil Immunomodulatory Activity of Nerolidol, a Major Component of Essential Oils fromPlants (Basel, Switzerland) · 2022Article
- Neutrophil Immunomodulatory Activity of (-)-Borneol, a Major Component of Essential Oils Extracted fromMolecules (Basel, Switzerland) · 2022Article
- Neutrophil Immunomodulatory Activity of Farnesene, a Component ofPharmaceuticals (Basel, Switzerland) · 2022Article
- Innate Immunomodulatory Activity of Cedrol, a Component of Essential Oils Isolated fromMolecules (Basel, Switzerland) · 2021Article
- Chemical Composition and Immunomodulatory Activity of Essential Oils fromMolecules (Basel, Switzerland) · 2021Article
- Essential Oils fromMolecules (Basel, Switzerland) · 2020Article
- Chemical Composition and Immunomodulatory Activity ofBiomolecules · 2020Article
- Neutrophil Immunomodulatory Activity of Natural Organosulfur Compounds.Molecules (Basel, Switzerland) · 2019Article
- Chemical Composition and Antibacterial Activity of Essential Oils fromMolecules (Basel, Switzerland) · 2018Article
- Chemical composition and phagocyte immunomodulatory activity ofJournal of leukocyte biology · 2017Article
- Anti-Inflammatory, Antioxidant, Antibiotic, and Cytotoxic Activities of Tanacetum vulgare L. Essential Oil and Its Constituents.Medicines (Basel, Switzerland) · 2017Article
- Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents.Journal of agricultural and food chemistry · 2016Article
- Antagonism of human formyl peptide receptor 1 with natural compounds and their synthetic derivatives.International immunopharmacology · 2016Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
Abstract
Essential oils were obtained by hydrodistillation of the flowers+leaves and stems of Artemisia kotuchovii Kupr. (AKEO(f+l) and AKEO(stm), respectively) and analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The primary components of the oils were estragole, (E)- and (Z)-β-ocimenes, methyleugenol, limonene, spathulenol, β-pinene, myrcene, and (E)-methyl cinnamate. Seventy-four constituents were present at concentrations from 0.1 to 1.0%, and 34 compounds were identified in trace (<0.1%) amounts in one or both plant components. Screening of the essential oils for biological activity showed that AKEO(stm), but not AKEOf+l, inhibited N-formyl-Met-Leu-Phe (fMLF)-stimulated Ca(2+) flux and chemotaxis and phorbol-12-myristate-13-acetate (PMA)-induced reactive oxygen species (ROS) production in human neutrophils. Selected pure constituents, representing >96% of the AKEO(stm) composition, were also tested in human neutrophils and HL-60 cells transfected with N-formyl peptide receptor 1 (FPR1). One component, 6-methyl-3,5-heptadien-2-one (MHDO), inhibited fMLF- and interleukin 8 (IL-8)-stimulated Ca(2+) flux, fMLF-induced chemotaxis, and PMA-induced ROS production in human neutrophils. MHDO also inhibited fMLF-induced Ca(2+) flux in FPR1-HL60 cells. These results suggest that MHDO may be effective in modulating some innate immune responses, possibly by inhibition of neutrophil migration and ROS production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.