ArticleInternational journal of clinical and experimental pathology2015
Resveratrol attenuates spinal cord injury-induced inflammatory damage in rat lungs.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03864198 (Evaluation of Treatment With Trans-resveratrol, Folic Acid, Vitamin D, Vitamin B12 and B6 in Men With Infertility), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Treatment With Trans-resveratrol, Folic Acid, Vitamin D, Vitamin B12 and B6 in Men With Infertility
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Neurological recovery and antioxidant effect of erythropoietin for spinal cord injury: A systematic review and meta-analysis.Frontiers in neurology · 2022Pooled it
- The therapeutic efficacy of resveratrol for acute lung injury-A meta-analysis of preclinical trials.Frontiers in pharmacology · 2022Pooled it
- Resveratrol and neuroprotection: modulation of cellular dynamics and signaling networks in neurodegenerative diseases.Inflammopharmacology · 2026Review
- Rapamycin prevents lung injury related to acute spinal cord injury in rats.Scientific reports · 2023Article
- Cervical spinal cord injury leads to injury and altered metabolism in the lungs.Brain communications · 2023Article
- Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury.Oxidative medicine and cellular longevity · 2022Review
- CK2 and protein kinases of the CK1 superfamily as targets for neurodegenerative disorders.Frontiers in molecular biosciences · 2022Review
- Resveratrol Can Attenuate Astrocyte Activation to Treat Spinal Cord Injury by Inhibiting Inflammatory Responses.Molecular neurobiology · 2021Review
- Article
- Sirtuins: Potential Therapeutic Targets for Defense against Oxidative Stress in Spinal Cord Injury.Oxidative medicine and cellular longevity · 2021Review
- Neurological recovery and antioxidant effects of resveratrol in rats with spinal cord injury: a meta-analysis.Neural regeneration research · 2020Article
- Mitigation of Radiation-induced Pneumonitis and Lung Fibrosis using Alpha-lipoic Acid and Resveratrol.Anti-inflammatory & anti-allergy agents in medicinal chemistry · 2020Article
- Protective effects of Asiatic acid against pelvic inflammatory disease in rats.Experimental and therapeutic medicine · 2019Article
- Activation of SIRT1 ameliorates LPS-induced lung injury in mice via decreasing endothelial tight junction permeability.Acta pharmacologica Sinica · 2019Article
- Resveratrol alleviates lipopolysaccharide-induced inflammation in PC-12 cells and in rat model.BMC biotechnology · 2019Article
- Inhibition of NF-κB Signaling Pathway by Resveratrol Improves Spinal Cord Injury.Frontiers in neuroscience · 2018Review
- A Study of the Therapeutic Effects of Resveratrol on Blunt Chest Trauma-Induced Acute Lung Injury in Rats and the Potential Role of Endocan as a Biomarker of Inflammation.Inflammation · 2017Article
- Regulation of autophagy by AMP-activated protein kinase/sirtuin 1 pathway reduces spinal cord neurons damage.Iranian journal of basic medical sciences · 2017Article
- Resveratrol and Alzheimer's Disease: Mechanistic Insights.Molecular neurobiology · 2017Review
- Neural Stem Cell-Conditioned Medium Suppresses Inflammation and Promotes Spinal Cord Injury Recovery.Cell transplantation · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal cord injury (SCI)-induced systemic inflammatory response affects multiple organs outside the spinal cord. Treatment options for such complications are lacking. We studied the potential protective effects of resveratrol on SCI-induced inflammatory damage in rat lungs. Sprague-Dawley rats were subjected to weight-drop impact at the T10 vertebral level with administration of resveratrol (100 mg/kg) or vehicle (via the intraperitoneal route) immediately after trauma. Lung injury was studied by measuring: vascular permeability-related pulmonary edema; histopathologic scores, neutrophil infiltration and concentrations of inflammatory cytokines in bronchoalveolar fluid; expression of inflammatory enzymes and sirtuin (SIRT) 1 as well as nuclear factor-kappa B (NF-κB) activity in pulmonary tissues. Resveratrol treatment significantly alleviated SCI-induced pulmonary edema as indicated by the ratio of the wet weight to dry weight of lung tissue and pulmonary permeability index. Resveratrol significantly reduced neutrophil infiltration and production of inflammatory mediators. Resveratrol treatment was accompanied by up-regulation of expression of SIRT1 and suppression of NF-κB activity in pulmonary tissues. These data suggest that resveratrol may protect the lungs from SCI-induced inflammatory damage, and could be used as a therapeutic option against pulmonary problems after SCI.
Indexed as
Identifiers
25973008PMC4396266W2403236246What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.