Evidence map›Paper›PMID 25975969›Full record

Trial reportMedical science monitor : international medical journal of experimental and clinical research2015

Neuroprotective effects of intravenous lidocaine on early postoperative cognitive dysfunction in elderly patients following spine surgery.

Kui Chen, Penghui Wei, Qiang Zheng, Jinfeng Zhou, Jianjun Li

Registry-linked trialOpen access · hybridAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medical science monitor : international medical journal of experimental and clinical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03018522 (S100B Protein as Predictor of Cognitive Dysfunction After Robot-assisted Radical Prostatectomy), which is not on this map. Cited by 39 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 4 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03018522 completednot on this mapstarted 2017, after this paper: background citation

S100B Protein as Predictor of Cognitive Dysfunction After Robot-assisted Radical Prostatectomy: A Prospective Observational Study

TypeobservationalSponsorAntalya Training and Research HospitalRan2017 to 2018Enrolled89ConditionsPostoperative Cognitive DysfunctionArmsPostoperative cognitive dysfunction
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 4 syntheses or guidelines pooled it, 70 citations in OpenAlex.

  1. Pooled it
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  10. Effect of ketamine combined with lidocaine in pediatric anesthesia.Journal of clinical laboratory analysis · 2020
    Trial
  11. Lidocaine Reduces Sevoflurane Consumption and Improves Recovery Profile in Children Undergoing Major Spine Surgery.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Trial
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  14. Review
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  19. Postoperative cognitive dysfunction: a concept analysis.Aging clinical and experimental research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kui ChenDepartment of Anesthesiology, Qilu Hospital, Shandong University, Jinan, Shandong, China (mainland).
Penghui WeiDepartment of Anesthesiology, Qilu Hospital, Shandong University, Jinan, Shandong, China (mainland).
Qiang ZhengDepartment of Anesthesiology, Qilu Hospital, Shandong University, Jinan, Shandong, China (mainland).
Jinfeng ZhouDepartment of Anesthesiology, Qilu Hospital, Shandong University, Jinan, Shandong, China (mainland).
Jianjun LiDepartment of Anesthesiology, Qilu Hospital, Shandong University, Jinan, Shandong, China (mainland).
Qilu Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to evaluate the effects of lidocaine treatment on cognitive impairment in aged patients undergoing spine surgery and to explore the underlying mechanism. MATERIAL/

methodsPatients were randomly divided into 2 treatment groups: (1) saline (control) and (2) lidocaine. After induction of anesthesia, the lidocaine group received lidocaine as a bolus of 1 mg/kg over 5 minutes, followed by a continuous infusion at 1.5 mg/kg/h until the end of the surgery. We examined the effects of lidocaine treatment on the improvement of cognitive function using the Mini-Mental State Examination (MMSE) at preoperation and 3 days postoperation. Serum samples were collected to assess the levels of IL-6, TNF-α, MDA, S100β, and NSE before inducing anesthesia, at the end of surgery, and 3 days after the end of surgery.

resultsWe found that the MMSE scores in the lidocaine group were markedly higher than those in the control group at 3 days after surgery. Moreover, lidocaine treatment markedly suppressed the release of IL-6, S100β, and NSE into the serum at the end of surgery and 3 days after the end of surgery. In the control group, serum MDA levels increased by 3 days after the end of surgery. The lidocaine group had lower serum MDA levels than those in the control group.

conclusionsLidocaine may be an effective neuroprotective agent in treating early postoperative cognitive dysfunction in elderly patients undergoing spine surgery.

Indexed as

NeurosurgeryAgedAged, 80 and overAnesthesia, GeneralCognition DisordersFemaleHumansInfusions, IntravenousInterleukin-6LidocaineMaleMalondialdehydeNeuroprotective AgentsNeuropsychological TestsPhosphopyruvate HydratasePostoperative ComplicationsIL6 protein, humanInterleukin-6LidocaineMalondialdehydeNeuroprotective AgentsPhosphopyruvate HydrataseS100B protein, humanS100 Calcium Binding Protein beta SubunitTumor Necrosis Factor-alpha

Identifiers

PMID25975969
PMCPMC4444175
OpenAlexW1952217706

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.