ArticleScientific reports2015
Diabetic silkworms for evaluation of therapeutically effective drugs against type II diabetes.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Trial
- The silkworm: A promising invertebrate diabetes model for natural drug discovery.Global health & medicine · 2025Review
- Nature's blueprint for sugar metabolism: translating bee and ant strategies into human diabetes therapies.Diabetology & metabolic syndrome · 2025Review
- Development of a silkworms-based evaluation system for the extracts and compounds for their obesity and lipid metabolism improving activity.Scientific reports · 2025Article
- Article
- Mechanism of hyperproteinemia-induced damage to female reproduction in a genetic silkworm model.iScience · 2023Article
- Lycium barbarum polysaccharide improves dopamine metabolism and symptoms in an MPTP-induced model of Parkinson's disease.BMC medicine · 2022Article
- Advances in Editing Silkworms (Insects · 2021Review
- Effect of black ginseng and silkworm supplementation on obesity, the transcriptome, and the gut microbiome of diet-induced overweight dogs.Scientific reports · 2021Article
- Article
- Evaluation of the silkwormRoyal Society open science · 2020Article
- Overexpression of BmFoxO inhibited larval growth and promoted glucose synthesis and lipolysis in silkworm.Molecular genetics and genomics : MGG · 2019Article
- Silkworm as an experimental animal for research on fungal infections.Microbiology and immunology · 2019Review
- Silkworm, Bombyx mori, as an alternative model organism in toxicological research.Environmental science and pollution research international · 2018Article
- Silkworm: A Promising Model Organism in Life Science.Journal of insect science (Online) · 2017Review
- An in vivo invertebrate evaluation system for identifying substances that suppress sucrose-induced postprandial hyperglycemia.Scientific reports · 2016Article
- Fishing for Nature's Hits: Establishment of the Zebrafish as a Model for Screening Antidiabetic Natural Products.Evidence-based complementary and alternative medicine : eCAM · 2015Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously reported that sugar levels in the silkworm hemolymph, i.e., blood, increase immediately (within 1 h) after intake of a high-glucose diet, and that the administration of human insulin decreases elevated hemolymph sugar levels in silkworms. In this hyperglycemic silkworm model, however, administration of pioglitazone or metformin, drugs used clinically for the treatment of type II diabetes, have no effect. Therefore, here we established a silkworm model of type II diabetes for the evaluation of anti-diabetic drugs such as pioglitazone and metformin. Silkworms fed a high-glucose diet over a long time-period (18 h) exhibited a hyperlipidemic phenotype. In these hyperlipidemic silkworms, phosphorylation of JNK, a stress-responsive protein kinase, was enhanced in the fat body, an organ that functionally resembles the mammalian liver and adipose tissue. Fat bodies isolated from hyperlipidemic silkworms exhibited decreased sensitivity to human insulin. The hyperlipidemic silkworms have impaired glucose tolerance, characterized by high fasting hemolymph sugar levels and higher hemolymph sugar levels in a glucose tolerance test. Administration of pioglitazone or metformin improved the glucose tolerance of the hyperlipidemic silkworms. These findings suggest that the hyperlipidemic silkworms are useful for evaluating the hypoglycemic activities of candidate drugs against type II diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.