Evidence map›Paper›PMID 26035484›Full record

ReviewTissue engineering. Part B, Reviews2015

Lysophosphatidic Acid and Sphingosine-1-Phosphate: A Concise Review of Biological Function and Applications for Tissue Engineering.

Bernard Y K Binder, Priscilla A Williams, Eduardo A Silva, J Kent Leach

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Tissue engineering. Part B, Reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Autotaxin/Lysophosphatidic Acid Axis: From Bone Biology to Bone Disorders.International journal of molecular sciences · 2022
    Review
  8. Review
  9. Review
  10. [Research progress on the biological regulatory function of lysophosphatidic acid in bone tissue cells].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2020
    Review
  11. Article
  12. Article
  13. Generic chemoprevention of hepatocellular carcinoma.Annals of the New York Academy of Sciences · 2019
    Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Bernard Y K Binder1 Department of Biomedical Engineering, University of California , Davis, Davis, California.
Priscilla A Williams1 Department of Biomedical Engineering, University of California , Davis, Davis, California.
Eduardo A Silva1 Department of Biomedical Engineering, University of California , Davis, Davis, California.
J Kent Leach1 Department of Biomedical Engineering, University of California , Davis, Davis, California.
University of California, Davis · US

Funding

Phospholipids for enhancing cell-based neovascularizationR21AG036963 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEACH, J. KENT · 2010 to 2011
$339k
NIA NIH HHS 1R21AG036963
6 · The paper itself

Abstract

The presentation and controlled release of bioactive signals to direct cellular growth and differentiation represents a widely used strategy in tissue engineering. Historically, work in this field has primarily focused on the delivery of large cytokines and growth factors, which can be costly to manufacture and difficult to deliver in a sustained manner. There has been a marked increase over the past decade in the pursuit of lipid mediators due to their wide range of effects over multiple cell types, low cost, and ease of scale-up. Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are two bioactive lysophospholipids (LPLs) that have gained attention for use as pharmacological agents in tissue engineering applications. While these lipids can have similar effects on cellular response, they possess distinct chemical backbones, mechanisms of synthesis and degradation, and signaling pathways using a discrete set of G-protein-coupled receptors (GPCRs). LPA and S1P predominantly act extracellularly on their GPCRs and can directly regulate cell survival, differentiation, cytokine secretion, proliferation, and migration--each of the important functions that must be considered in regenerative medicine. In addition to these potent physiological functions, these LPLs play pivotal roles in a number of pathophysiological processes. To capitalize on the promise of these molecules in tissue engineering, these lipids have been incorporated into biomaterials for in vivo delivery. Here, we survey the effects of LPA and S1P on both cellular- and tissue-level phenotypes, with an eye toward regulating stem/progenitor cell growth and differentiation. In particular, we examine work that has translational applications for cell-based tissue engineering strategies in promoting cell survival, bone and cartilage engineering, and therapeutic angiogenesis.

Indexed as

AnimalsCell DifferentiationCell MovementHumansLysophospholipidsReceptors, G-Protein-CoupledSphingosineStem CellsTissue Engineeringlysophosphatidic acidLysophospholipidsReceptors, G-Protein-CoupledSphingosinesphingosine 1-phosphate

Identifiers

PMID26035484
PMCPMC4663652
OpenAlexW2226437959

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.