Evidence map›Paper›PMID 26039520›Full record

ArticleThe New England journal of medicine2015

Proof That Lower Is Better--LDL Cholesterol and IMPROVE-IT.

John A Jarcho, John F Keaney

Abstract readEditorialComment
PubMed Publisher
In one paragraph

Article in The New England journal of medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Pooled it
  5. PCSK-9-inhibitor therapy improves endothelial function in high-risk patients with cardiovascular disease.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

John A JarchoFrom the University of Massachusetts Medical School, Worcester, MA (J.F.K.).
John F Keaney

Funding

Nox4 and Vascular HomeostasisR01HL098407 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KEANEY, JOHN FRANCIS · 2010 to 2017
$3.8M
Mitochondrial Modulation of Endothelia FunctionR01HL092122 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KEANEY, JOHN FRANCIS · 2009 to 2016
$3.3M
NHLBI NIH HHS R01 HL092122NHLBI NIH HHS R01 HL098407
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Acute Coronary SyndromeAnticholesteremic AgentsAzetidinesCholesterol, LDLFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleSimvastatinAnticholesteremic AgentsAzetidinesCholesterol, LDLHydroxymethylglutaryl-CoA Reductase InhibitorsSimvastatin

Identifiers

PMID26039520

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.