SynthesisMedical science monitor : international medical journal of experimental and clinical research2015
Association of alpha-ADD1 Gene and Hypertension Risk: A Meta-Analysis.
Synthesis in Medical science monitor : international medical journal of experimental and clinical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- The role of DNA methylation and histone modifications in blood pressure: a systematic review.Journal of human hypertension · 2019Pooled it
- Epigenetic Changes Related to Hypertension in Asian Adults: A Systematic Review.Chronic diseases and translational medicine · 2025Review
- Evaluation of angiotensin converting enzyme insertion/deletion, alpha adducin (ADD1) G460W, and IL-10 gene polymorphisms, and determination of prognostic effects in idiopathic sudden sensorineural hearing loss.Journal of otology · 2024Article
- The Association between Gly460Trp-Polymorphism of Alpha-Adducin 1 Gene (International journal of hypertension · 2021Article
- Review
- Relationship between a Weighted Multi-Gene Algorithm and Blood Pressure Control in Hypertension.Journal of clinical medicine · 2019Article
- A Review of the Epidemiological Evidence for Adducin Family Gene Polymorphisms and Hypertension.Cardiology research and practice · 2019Review
- The Effect of Genetically Guided Mathematical Prediction and the Blood Pressure Response to Pharmacotherapy in Hypertension Patients.Clinical Medicine Insights. Cardiology · 2019Article
- A Review on Adducin from Functional to Pathological Mechanisms: Future Direction in Cancer.BioMed research international · 2018Review
- Relationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira Island.Medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundResults regarding the association between a-adducin (ADD1) gene and essential hypertension (EH) risk remain inconsistent. Therefore, we performed this meta-analysis to investigate this association. MATERIAL AND
methodsWe comprehensively searched published literature from PubMed and Embase. All studies analyzing the association between ADD1 Gly460Trp polymorphism and EH risk were included. Fixed- or random-effects model was used to calculate pooled odds ratio (OR) with 95% confidence interval (CI).
resultsData synthesis showed an increased risk of EH in T allele variant carriers with Asian descent, for GG vs. TT (OR=0.750, 95%CI: 0.585-0.960; P=0.022), recessive model (OR=1.196, 95%CI: 1.009-1.418; P=0.039), dominant model (OR=0.826, 95%CI: 0.693-0.985; P=0.033), and allelic model (OR=0.859, 95%CI: 0.756-0.964; P=0.01), respectively. However, no statistical differences were observed in Blacks and Caucasians.
conclusionsThe findings showed the association of the T allele in ADD1 gene with EH susceptibility in Asians. However, well-designed studies involving gene-gene and gene-environment interactions should be considered in future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.