Evidence map›Paper›PMID 26045702›Full record

ArticleHepatitis monthly2015

Distribution and epidemiologic trends of HBV genotypes and subtypes in 14 countries neighboring china.

Zhao Qian, Wang Jianqiong, Li Hongmei, Zeng Rong, Li Li, Zhang Jinping, Shen Tao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hepatitis monthly, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zhao QianKunming Medical College, Kunming, Yunnan, China ; Institute of Basic and Clinical Medicine, Provincial Key Laboratory for Birth Defects and Genetic Diseases, the First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming Science and Technology University, Kunming, Yunnan Province, China.
Wang JianqiongClinical Laboratory, the First People's Hospital of Yunnan Province, Kunming, Yunnan Province, China.
Li HongmeiInstitute of Basic and Clinical Medicine, Provincial Key Laboratory for Birth Defects and Genetic Diseases, the First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming Science and Technology University, Kunming, Yunnan Province, China ; Kunming Science and Technology University, Kunming, Yunnan, China.
Zeng RongInstitute of Basic and Clinical Medicine, Provincial Key Laboratory for Birth Defects and Genetic Diseases, the First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming Science and Technology University, Kunming, Yunnan Province, China.
Li LiInstitute of Basic and Clinical Medicine, Provincial Key Laboratory for Birth Defects and Genetic Diseases, the First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming Science and Technology University, Kunming, Yunnan Province, China.
Zhang JinpingInstitute of Basic and Clinical Medicine, Provincial Key Laboratory for Birth Defects and Genetic Diseases, the First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming Science and Technology University, Kunming, Yunnan Province, China.
Shen TaoInstitute of Basic and Clinical Medicine, Provincial Key Laboratory for Birth Defects and Genetic Diseases, the First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming Science and Technology University, Kunming, Yunnan Province, China.
First People's Hospital of Yunnan Province · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe number of cases of HBV infection reported by the WHO for each district and country is positively correlated with the number of HBV sequences in the database isolated from the corresponding district and country.

objectivesThis study determined distribution characteristics of HBV genotypes and subtypes in 14 countries neighboring China. The progress made in genomic research involving HBV was also reviewed. MATERIALS AND

methodsNine hundred fifty-one complete genome sequences of HBV from 14 countries neighboring China were selected from NCBI. The sequence-related information was analyzed and recorded. One hundred seventy-two sequences of HBV genotype B were screened for alignment using DNA star and MEGA 5.1.

resultsDominant HBV genotypes in the countries neighboring China were genotypes B, C and D and dominant subtypes were adw2 and adrq+. The association between genotype and serotype of HBV in these countries was shown to differ from previous research results. As shown by sequence alignment, the sequence divergence between five subgenotypes (B3, B5, B7, B8 and B9) was below 4%. The B subgenotypes shared six common specific amino acid sites in the S region.

conclusionsThe B3, B5, B7, B8 and B9 subgenotypes can be clustered into quasi-sub-genotype B3 and the open reading frame of HBV has a start codon preference; however, whether a mutation in the start codon in the pre-S2 region has an impact on survival and replication of HBV remains to be determined.

Indexed as

EpidemiologyGenomicsSerotype

Identifiers

PMID26045702
PMCPMC4451280
OpenAlexW428292725

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.