Evidence map›Paper›PMID 26064976›Full record

Trial reportJournal of diabetes research2015

Vinegar Consumption Increases Insulin-Stimulated Glucose Uptake by the Forearm Muscle in Humans with Type 2 Diabetes.

Panayota Mitrou, Eleni Petsiou, Emilia Papakonstantinou, Eirini Maratou, Vaia Lambadiari, Panayiotis Dimitriadis, Filio Spanoudi, Sotirios A Raptis, George Dimitriadis

3 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of diabetes research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02309424 nacompletednot on this map

The Effect of Vinegar on Glucose and Lipid Metabolism in Peripheral Tissues in Subjects With Impaired Glucose Tolerance or Type 2 Diabetes

TypeinterventionalSponsorAttikon HospitalRan2008 to 2014Enrolled20ConditionsType 2 DiabetesArmsVinegar, Placebo
NCT02649140 naunknown statusnot on this map

The Effect of Vinegar Consumption on 24-hour Urinary Risk Factors Associated With Calcium Oxalate Urinary Stone Formation: a Randomised Controlled Trial

TypeinterventionalSponsorThe First Affiliated Hospital of Guangzhou Medical UniversityRan2015 to 2016Enrolled50ConditionsUrolithiasisArmsVinegar group
NCT03596099 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Rice Vinegar as an Intervention to Lower Blood Pressure in Adults With Prehypertension and 10-year CVD Risk <10%

TypeinterventionalSponsorMizkan Holdings Co., Ltd.Ran2018 to 2019Enrolled130ConditionsPrehypertensionArmsMizkan rice vinegar with acetic acid, Mizkan rice vinegar without acetic acid
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
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  15. Health Promoting Properties of Cereal Vinegars.Foods (Basel, Switzerland) · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Panayota MitrouHellenic National Center for Research, Prevention and Treatment of Diabetes Mellitus and Its Complications (HNDC), 3 Ploutarchou Street, 10675 Athens, Greece.
Eleni Petsiou2nd Department of Internal Medicine and Research Institute, Athens University Medical School, Attikon University Hospital, 1 Rimini Street, 12462 Haidari, Greece.ORCID 0000-0002-3944-1415
Emilia Papakonstantinou2nd Department of Internal Medicine and Research Institute, Athens University Medical School, Attikon University Hospital, 1 Rimini Street, 12462 Haidari, Greece.ORCID 0000-0002-7753-8154
Eirini MaratouHellenic National Center for Research, Prevention and Treatment of Diabetes Mellitus and Its Complications (HNDC), 3 Ploutarchou Street, 10675 Athens, Greece.
Vaia Lambadiari2nd Department of Internal Medicine and Research Institute, Athens University Medical School, Attikon University Hospital, 1 Rimini Street, 12462 Haidari, Greece.
Panayiotis DimitriadisDepartment of Water Resources and Environmental Engineering, School of Civil Engineering, NTUA, Heroon Polytechniou 5-9, 15780 Athens, Greece.
Filio Spanoudi2nd Department of Internal Medicine and Research Institute, Athens University Medical School, Attikon University Hospital, 1 Rimini Street, 12462 Haidari, Greece.
Sotirios A RaptisHellenic National Center for Research, Prevention and Treatment of Diabetes Mellitus and Its Complications (HNDC), 3 Ploutarchou Street, 10675 Athens, Greece ; 2nd Department of Internal Medicine and Research Institute, Athens University Medical School, Attikon University Hospital, 1 Rimini Street, 12462 Haidari, Greece.
George Dimitriadis2nd Department of Internal Medicine and Research Institute, Athens University Medical School, Attikon University Hospital, 1 Rimini Street, 12462 Haidari, Greece.
University General Hospital Attikon · GRHellenic Center for Disease Control & Prevention · GRNational Technical University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsVinegar has been shown to have a glucose-lowering effect in patients with glucose abnormalities. However, the mechanisms of this effect are still obscure. The aim of this randomised, crossover study was to investigate the effect of vinegar on glucose metabolism in muscle which is the most important tissue for insulin-stimulated glucose disposal. MATERIALS AND

methodsEleven subjects with DM2 consumed vinegar or placebo (at random order on two separate days, a week apart), before a mixed meal. Plasma glucose, insulin, triglycerides, nonesterified fatty acids (NEFA), and glycerol were measured preprandially and at 30-60 min for 300 min postprandially from the radial artery and from a forearm vein. Muscle blood flow was measured with strain-gauge plethysmography. Glucose uptake was calculated as the arteriovenous difference of glucose multiplied by blood flow.

resultsVinegar compared to placebo (1) increased forearm glucose uptake (p = 0.0357), (2) decreased plasma glucose (p = 0.0279), insulin (p = 0.0457), and triglycerides (p = 0.0439), and (3) did not change NEFA and glycerol.

conclusionsIn DM2 vinegar reduces postprandial hyperglycaemia, hyperinsulinaemia, and hypertriglyceridaemia without affecting lipolysis. Vinegar's effect on carbohydrate metabolism may be partly accounted for by an increase in glucose uptake, demonstrating an improvement in insulin action in skeletal muscle. This trial is registered with Clinicaltrials.gov NCT02309424.

Indexed as

Acetic AcidBlood GlucoseCross-Over StudiesDiabetes Mellitus, Type 2FemaleForearmGlucoseHumansInsulinLipidsMaleMiddle AgedMuscle, SkeletalPostprandial PeriodRegional Blood FlowAcetic AcidBlood GlucoseGlucoseInsulinLipids

Identifiers

PMID26064976
PMCPMC4438142
OpenAlexW1574196797

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.