Evidence map›Paper›PMID 26066358›Full record

ArticleJournal of autism and developmental disorders2015

Parents' perceptions of the usefulness of chromosomal microarray analysis for children with autism spectrum disorders.

Marian Reiff, Ellen Giarelli, Barbara A Bernhardt, Ebony Easley, Nancy B Spinner, Pamela L Sankar, Surabhi Mulchandani

Abstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Systematic Review: The Psychosocial Impacts of Autism-Related Genetic Testing.Journal of the American Academy of Child and Adolescent Psychiatry · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Personal utility in genomic testing: a systematic literature review.European journal of human genetics : EJHG · 2017
    Pooled it
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  10. Impact of a Genetic Diagnosis for a Child's Autism on Parental Perceptions.Journal of autism and developmental disorders · 2025
    Article
  11. Article
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  13. Decoding the genetic landscape of autism: A comprehensive review.World journal of clinical pediatrics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marian ReiffDivision of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Penn Tower Room 1112, Philadelphia, PA, 19104, USA. marian.reiff@uphs.upenn.edu.ORCID http://orcid.org/0000-0003-1199-6598
Ellen GiarelliCollege of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA.
Barbara A BernhardtDivision of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Penn Tower Room 1112, Philadelphia, PA, 19104, USA.
Ebony EasleyMixed Methods Research Lab, University of Pennsylvania, Philadelphia, PA, USA.
Nancy B SpinnerDivision of Genomic Diagnostics and Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Pamela L SankarDepartment of Medical Ethics and Health Policy, University of Pennsylvania, Philadelphia, PA, USA.
Surabhi MulchandaniDivision of Genomic Diagnostics and Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Funding

The impact of uncertainty in genome-wide testing for Autism Spectrum DisorderR21HG006560 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI REIFF, MARIAN F · 2012 to 2013
$440k
NHGRI NIH HHS R21 HG006560
6 · The paper itself

Abstract

Clinical guidelines recommend chromosomal microarray analysis (CMA) for all children with autism spectrum disorders (ASDs). We explored the test's perceived usefulness among parents of children with ASD who had undergone CMA, and received a result categorized as pathogenic, variant of uncertain significance, or negative. Fifty-seven parents participated in a semi-structured telephone interview, and 50 also completed a survey. Most parents reported that CMA was helpful for their child and family. Major themes regarding perceived usefulness were: medical care, educational and behavioral interventions, causal explanation, information for family members, and advancing knowledge. Limits to utility, uncertainties and negative outcomes were also identified. Our findings highlight the importance of considering both health and non-health related utility in genomic testing.

Indexed as

Genetic TestingPatient Acceptance of Health CareAutism Spectrum DisorderChildChild, PreschoolFemaleHumansMaleMicroarray AnalysisParentsAutism spectrum disordersChromosomal microarray analysisGenomic testingParent perspectivesPerceived utilityQualitative

Identifiers

PMID26066358
PMCPMC4573251

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.