DPP-4 inhibitors × adverse events & safety

SynthesisScientific reports2015

Pharmacologic Therapy of Diabetes and Overall Cancer Risk and Mortality: A Meta-Analysis of 265 Studies.

Lang Wu et al.PubMed ↗Full text ↗Publisher ↗

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Went with lower adverse events & safety

−14%−17% to −10%

Bigger than 4 in 10 for adverse events & safety

As reported

RR 0.86, 95% CI 0.83–0.90

Correlation, not cause

Went with lower adverse events & safety

−7%−9% to −4%

Bigger than 3 in 10 for adverse events & safety

As reported

RR 0.93, 95% CI 0.91–0.96

Correlation, not cause

Went with higher glycemic control

+21%+8% to +36%

Bigger than 1 in 10 for glycemic control

As reported

RR 1.21, 95% CI 1.08–1.36

+7 more in the walkthrough ↓

Ten numbers in the abstract

the abstract, start to end

a lower risk of cancer incidence (RR = 0.86, 95% CI 0.83-0.90, I(2) = 88.61%; RR = 0.93, 95% CI 0.91-0.96, I(2) = 0.00%

increased risk of cancer incidence (RR = 1.21, 95% CI 1.08-1.36, I(2) = 96.31%; RR = 1.20, 95% CI 1.13-1.27, I(2) = 95.02%; RR = 1.10, 95% CI 1.05-1.15, I(2) = 0.00%

with the risk of cancer (7 studies, RR = 0.90, 95% CI 0.49-1.65) (Table 1i).

risk of cancer (72 studies, RR = 1.20, 95% CI 1.13-1.27) (Table 1c).

risk of cancer (73 studies; RR = 1.21, 95% CI 1.08-1.36) (Table 1a).

risk of cancer (13 studies, RR =  1.10, 95% CI 1.05-1.15) (Table 2f).

associated with the risk of cancer (RR = 0.92, 95% CI 0.82-1.04) (Table 1e).

← favours treatmentfavours comparator →
could be chance
Adverse events & safety
RR 0.860.83–0.90
Adverse events & safety
RR 0.930.91–0.96
Glycemic control
RR 1.211.08–1.36
Glycemic control
RR 1.201.13–1.27
Glycemic control
RR 1.101.05–1.15
Adverse events & safety
RR 0.900.49–1.65
Adverse events & safety
RR 1.201.13–1.27
Glycemic control
RR 1.211.08–1.36
Adverse events & safety
RR 1.101.05–1.15
Adverse events & safety
RR 0.920.82–1.04
MetforminSGLT2 inhibitorsGLP-1 receptor agonistsDPP-4 inhibitorsSulfonylureas & glinidesThiazolidinedionesInsulinOther glucose-loweringGlycemic controlAdverse events & safety
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