Evidence map›Paper›PMID 26082911›Full record

ArticleThe Journal of frailty & aging2013

Current nutritional recommendations and novel dietary strategies to manage sarcopenia.

Riccardo Calvani, Alfredo Miccheli, Francesco Landi, Maurizio Bossola, Matteo Cesari, Christiaan Leeuwenburgh, Cornel C Sieber, Roberto Bernabei, Emanuele Marzetti

Open access · greenAbstract read
In one paragraph

Article in The Journal of frailty & aging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 8 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 8 syntheses or guidelines pooled it, 162 citations in OpenAlex.

  1. Pooled it
  2. Frontiers in nutrition · 2025
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  5. Protein Intake and Sarcopenia in Older Adults: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
    Pooled it
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29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Riccardo CalvaniItalian National Research Council (CNR), Institute of Crystallography, Bari 70126, Italy.
Alfredo MiccheliDepartment of Chemistry, Sapienza University of Rome, Rome 00185, Italy.
Francesco LandiDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart School of Medicine, Teaching Hospital "Agostino Gemelli", Rome 00168, Italy.
Maurizio BossolaDepartment of Surgery, Catholic University of the Sacred Heart School of Medicine, Teaching Hospital "Agostino Gemelli", Rome 00168, Italy.
Matteo CesariInstitut du Vieillissement, Gérontopôle and INSERM Unit 1027, Université de Toulouse, Toulouse 31000, France.
Christiaan LeeuwenburghDepartment of Aging and Geriatric Research, Institute on Aging, University of Florida, Gainesville, FL 32610, USA.
Cornel C SieberInstitute for Biomedicine of Aging, Friedrich Alexander University Erlangen-Nürnberg, Nürnberg, 90419, Germany.
Roberto BernabeiDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart School of Medicine, Teaching Hospital "Agostino Gemelli", Rome 00168, Italy.
Emanuele MarzettiDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart School of Medicine, Teaching Hospital "Agostino Gemelli", Rome 00168, Italy.
Agostino Gemelli University Polyclinic · ITUniversità Cattolica del Sacro Cuore · ITInstitute on Aging · USSapienza University of Rome · IT

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Stephen D Anton · 2007 to 2026
$22.8M
Apoptosis and Life-Long Caloric RestrictionR01AG021042 · NIA · UNIVERSITY OF FLORIDA · PI LEEUWENBURGH, CHRISTIAAN · 2003 to 2007
$1.7M
Mitophagy: target to improve liver function after ischemia/reperfusion injuryR01DK090115 · NIDDK · UNIVERSITY OF FLORIDA · PI KIM, JAE-SUNG, LEEUWENBURGH, CHRISTIAAN · 2012 to 2015
$1.3M
NIA NIH HHS P30 AG028740NIA NIH HHS R01 AG021042NIDDK NIH HHS R01 DK090115
6 · The paper itself

Abstract

Sarcopenia, the loss of skeletal muscle mass and function that occurs with aging, is associated with increased risk for several adverse health outcomes, including frailty, disability, falls, loss of independent living, and mortality. At present, no pharmacological treatment exists that is able to definitely halt the progression of sarcopenia. Likewise, no pharmacological remedies are yet available to prevent the onset of age-related muscle wasting. In this scenario, the combination of nutritional interventions and physical exercise appears to be the most effective strategy presently available for the management of sarcopenia. The purposes of this review are to summarize the current knowledge on the role of nutrition as a countermeasure for sarcopenia, illustrate the mechanisms of action of relevant dietary agents on the aging muscle, and introduce novel nutritional strategies that may help preserve muscle mass and function into old age. Issues related to the identification of the optimal timing of nutritional interventions in the context of primary and secondary prevention are also discussed. Finally, the prospect of elaborating personalized dietary and physical exercise recommendations through the implementation of integrated, high-throughput analytic approaches is illustrated.

Indexed as

agingcreatineomicsPachinko modelpersonalized dietproteinvitamin D

Identifiers

PMID26082911
PMCPMC4465574
OpenAlexW2244006745

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.