ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2015
Blood flow and muscle oxygenation during low, moderate, and maximal sustained isometric contractions.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Effects of Unilateral Conditioning Activity on Acute Performance Enhancement: A Systematic Review.Journal of sports science & medicine · 2022Pooled it
- Effects of a Ketogenic Diet on Muscle Fatigue in Healthy, Young, Normal-Weight Women: A Randomized Controlled Feeding Trial.Nutrients · 2020Trial
- Blackcurrant Alters Physiological Responses and Femoral Artery Diameter during Sustained Isometric Contraction.Nutrients · 2017Trial
- Differential effects of isometric and isotonic contraction on water- and hemoglobin oxygenation-related mri responses in skeletal muscle.European journal of applied physiology · 2026Article
- Human dorsiflexor muscles are resilient against voluntary activation failure following high-intensity interval exercise.European journal of applied physiology · 2026Article
- The interactive effects of biological sex and skeletal muscle fiber properties on knee-extensor muscle relaxation induced by TMS in unfatigued and fatigued states.European journal of applied physiology · 2026Article
- Effect of external pressure and muscle contraction on soft tissue oxygenation measured with near infrared spectroscopy.Bulletin of the Hospital for Joint Disease (2013) · 2026Article
- The Effect of Blood Flow Restriction Training on Rock Climbing Performance, Forearm Blood Oxygenation and Cardiovascular Responses.European journal of sport science · 2026Article
- Low-Load Blood Flow Restriction Training Enhances Brachial Blood Flow During Exercise but not Reactive Hyperemia in Experienced Climbers.Scandinavian journal of medicine & science in sports · 2026Article
- Evaluating the Intensity of Muscle Contraction by Near-Infrared Spectroscopy, a Potential Application for Scaling Muscle Spasm.Journal of biophotonics · 2025Article
- Sex-Based Effects on Muscle Oxygenation During Repeated Maximal Intermittent Handgrip Exercise.Sports (Basel, Switzerland) · 2025Article
- The effects of low vs. high rating of perceived exertion clamp exercise on performance, neuromuscular, and muscle oxygen saturation responses in females.European journal of applied physiology · 2025Article
- Repeated-sprint training with low lung volume voluntary hypoventilation performed continuously throughout each set in healthy females.Frontiers in physiology · 2025Article
- The effect of body-conforming passive wearable device with knee flexion taping on dynamic knee stability.Wearable technologies · 2025Article
- Reduced oxygen desaturation in the vastus lateralis of chronic stroke survivors during graded muscle contractions.Topics in stroke rehabilitation · 2024Article
- Assessment of Microvascular Hemodynamic Adaptations in Finger Flexors of Climbers.Bioengineering (Basel, Switzerland) · 2024Article
- Effects of the intensity, duration and muscle mass factors of isometric exercise on acute local muscle hemodynamic responses and systematic blood pressure regulation.Frontiers in bioengineering and biotechnology · 2024Article
- Endogenous and Exogenous Antioxidants in Skeletal Muscle Fatigue Development during Exercise.Antioxidants (Basel, Switzerland) · 2023Review
- Time course of changes in torque and neuromuscular parameters during a sustained isometric forearm flexion task to fatigue anchored to a constant rating of perceived exertion.Journal of musculoskeletal & neuronal interactions · 2022Article
- The effects of whole-body vibration amplitude on glucose metabolism, inflammation, and skeletal muscle oxygenation.Physiological reports · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A reduction of blood flow to active muscle will precipitate fatigue, and sustained isometric contractions produce intramuscular and compartmental pressures that can limit flow. The present study explored how blood flow and muscle oxygenation respond to isometric contractions at low, moderate, and maximal intensities. Over two visits, 10 males (26 ± 2 yr; means ± SD) performed 1-min dorsiflexion contractions at 30, 60, and 100% of maximal voluntary contraction (MVC) torque. Doppler ultrasound of the anterior tibial artery was used to record arterial diameter and mean blood velocity and to calculate absolute blood flow. The tissue oxygenation index (TOI) of tibialis anterior was acquired with near-infrared spectroscopy (NIRS). There was a progressive increase in blood flow at 30% MVC (peak of 289 ± 139% resting value), no change from rest until an increase in the final 10 s of exercise at 60% MVC (peak of 197 ± 102% rest), and an initial decrease (59 ± 30% resting value) followed by a progressive increase at 100% MVC (peak of 355 ± 133% rest). Blood flow was greater at 30 and 100% than 60% MVC during the last 30 s of exercise. TOI was ∼63% at rest and, within 30 s of exercise, reached steady-state values of ∼42%, ∼22%, and ∼22% for 30, 60, and 100% MVC, respectively. Even maximal contraction of the dorsiflexors is unable to cause more than a transient decrease of flow in the anterior tibial artery. Unlike dynamic or intermittent isometric exercise, our results indicate blood flow is not linearly graded with intensity or directly coupled with oxygenation during sustained isometric contractions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.