Evidence map›Paper›PMID 26100142›Full record

ReviewTrends in neurosciences2015

Regulation of dendrite morphogenesis by extrinsic cues.

Pamela Valnegri, Sidharth V Puram, Azad Bonni

Open access · greenAbstract readReview
In one paragraph

Review in Trends in neurosciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 81 citations in OpenAlex.

  1. Late Endosome Transport by RILP-RAB7A Promotes Dendrite Arborization Independently of Degradation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Neuronal Activity Suppresses NEUROD-Dependent Transcription and Genome Organization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
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  4. Late endosome transport by RILP-RAB7A promotes dendrite arborization.bioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Pamela ValnegriDepartment of Anatomy and Neurobiology, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Sidharth V PuramDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Azad BonniDepartment of Anatomy and Neurobiology, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: bonni@wustl.edu.
Harvard University · USWashington University in St. Louis · US

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
REGULATION OF DENDRITE MORPHOGENESIS BY A CONTROSOMAL CAMKIIB SIGNALING PATHWAYR01NS084393 · NINDS · WASHINGTON UNIVERSITY · PI BONNI, AZAD · 2014 to 2018
$1.9M
NIGMS NIH HHS T32 GM007753NINDS NIH HHS NS084393NINDS NIH HHS R01 NS084393
6 · The paper itself

Abstract

Dendrites play a central role in the integration and flow of information in the nervous system. The morphogenesis and maturation of dendrites is hence an essential step in the establishment of neuronal connectivity. Recent studies have uncovered crucial functions for extrinsic cues in the development of dendrites. We review the contribution of secreted polypeptide growth factors, contact-mediated proteins, and neuronal activity in distinct phases of dendrite development. We also highlight how extrinsic cues influence local and global intracellular mechanisms of dendrite morphogenesis. Finally, we discuss how these studies have advanced our understanding of neuronal connectivity and have shed light on the pathogenesis of neurodevelopmental disorders.

Indexed as

CuesAnimalsCalcium SignalingDendritesHumansMorphogenesisNerve Growth FactorsNerve Tissue ProteinsNeuronsNeurotransmitter AgentsNerve Growth FactorsNerve Tissue ProteinsNeurotransmitter Agentscalcium signalingcontact-mediated regulatorsdendrite morphogenesisneuronal activitysecreted polypeptide growth factors

Identifiers

PMID26100142
PMCPMC4492469
OpenAlexW1529411207

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.