ArticlePediatric research2015
Decreased renal function in overweight and obese prepubertal children.
Article in Pediatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Obesity‑related kidney disease: a review on ultrasound applications.Italian journal of pediatrics · 2025Review
- Tracking the Prevalence of Obesity in Portuguese School-Aged Children: What Future to Expect?Children (Basel, Switzerland) · 2024Article
- Prevalence and associated factors of impaired kidney functions among children and adolescents in India: insights from the Comprehensive National Nutrition Survey (CNNS) 2016-18.BMC pediatrics · 2024Article
- Sex-Related Differences in Cardiovascular Risk in Adolescents with Overweight or Obesity.Reviews in cardiovascular medicine · 2024Article
- Mother-child correlation of kidney function: data from the Yamanashi Adjunct Study of Japan Environment and Children's Study (JECS).Pediatric nephrology (Berlin, Germany) · 2024Article
- Changes in Kidney Function Among Malaysian Adolescents and Its Determinants.Kidney international reports · 2023Article
- Pharmacokinetics and Proposed Dosing of Levetiracetam in Children With Obesity.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2023Article
- Early childhood fluoride exposure and preadolescent kidney function.Environmental research · 2022Article
- Dietary patterns and PFAS plasma concentrations in childhood: Project Viva, USA.Environment international · 2021Article
- Can childhood obesity influence later chronic kidney disease?Pediatric nephrology (Berlin, Germany) · 2019Review
- Evaluation of Renal Function in Obese Children and Adolescents Using Serum Cystatin C Levels, Estimated Glomerular Filtration Rate Formulae and Proteinuria: Which is most Useful?Journal of clinical research in pediatric endocrinology · 2019Observational
- Influence of the 6-month physical activity programs on renal function in obese boys.Pediatric research · 2018Article
- Metabolic risk factors in nondiabetic adolescents with glomerular hyperfiltration.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2017Article
- Longer duration of obesity is associated with a reduction in urinary angiotensinogen in prepubertal children.Pediatric nephrology (Berlin, Germany) · 2017Article
- Precocious obesity predisposes the development of more severe cisplatin-induced acute kidney injury in young adult mice.PloS one · 2017Article
- Normalization of glomerular filtration rate in obese children.Pediatric nephrology (Berlin, Germany) · 2016Article
- Effect of plasma NOx values on cardiac function in obese hypertensive and normotensive pediatric patients.Pediatric nephrology (Berlin, Germany) · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity is a potentially modifiable risk factor for the development and progression of kidney disease, both in adults and children. We aim to study the association of obesity and renal function in children, by comparing estimated glomerular filtration rate (eGFR) in nonoverweight and overweight/obese children. Secondarily, we aim to evaluate the accuracy of equations on eGFR estimation when compared to 24-h urinary creatinine clearance (CrCl).
methodsCross-sectional study of 313 children aged 8-9 y, followed in the birth cohort Generation XXI (Portugal). Creatinine and cystatin C, GFR estimated by several formulas and CrCl were compared in 163 nonoverweight and 150 overweight/obese, according to World Health Organization growth reference.
resultsOverweight/obese children had significantly lower eGFR, estimated by all methods, except for CrCl and revised Schwartz formula. Despite all children having renal function in the normal range, eGFR decreased significantly with BMI z-score (differences ranging from -4.3 to -1.1 ml/min/1.73 m(2) per standard deviation of BMI). The Zappitelli combined formula presented the closest performance to CrCl, with higher correlation coefficients and higher accuracy values.
conclusionYoung prepubertal children with overweight/obesity already present significantly lower GFR estimations that likely represent some degree of renal impairment associated with the complex deleterious effects of adiposity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.