Evidence map›Paper›PMID 26156077›Full record

Trial reportJournal of lipid research2015

Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation.

C Lawrence Kien, Dwight E Matthews, Matthew E Poynter, Janice Y Bunn, Naomi K Fukagawa, Karen I Crain, David B Ebenstein, Emily K Tarleton, Robert D Stevens, Timothy R Koves and 1 more

2 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of lipid research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01612234 nacompletednot on this map

Palmitate Metabolism and Insulin Resistance

TypeinterventionalSponsorUniversity of VermontRan2010 to 2015Enrolled70ConditionsObesityArmsHigh palmitate or high oleate diet.
NCT03577119 nacompletednot on this mapstarted 2018, after this paper: background citation

Full-fat Yogurt and Glucose Tolerance

TypeinterventionalSponsorUniversity of Vermont Medical CenterRan2018 to 2022Enrolled13ConditionsPre-DiabetesArmsFull-fat yogurt, Non-fat yogurt
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

C Lawrence KienDepartments of Pediatrics, University of Vermont, Burlington, VT Medicine, University of Vermont, Burlington, VT.
Dwight E MatthewsMedicine, University of Vermont, Burlington, VT Chemistry, University of Vermont, Burlington, VT.
Matthew E PoynterMedicine, University of Vermont, Burlington, VT.
Janice Y BunnMedical Biostatistics, University of Vermont, Burlington, VT.
Naomi K FukagawaMedicine, University of Vermont, Burlington, VT.
Karen I CrainMedicine, University of Vermont, Burlington, VT.
David B EbensteinMedicine, University of Vermont, Burlington, VT.
Emily K TarletonCollege of Medicine Clinical Research Center, University of Vermont, Burlington, VT.
Robert D StevensDuke Molecular Physiology Institute, Duke University, Durham, NC.
Timothy R KovesDuke Molecular Physiology Institute, Duke University, Durham, NC.
Deborah M MuoioDuke Molecular Physiology Institute, Duke University, Durham, NC.
University of Vermont · USDuke University · USUniversity of Vermont Medical Center · US

Funding

WEIGHT MAINTENANCE AND PSYCHOLOGICAL BENEFITS OF EXERCISEM01RR000109 · NCRR · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI BROCK, DAVID W · 1985 to 2010
$24.3M
Role of Carnitine Acetyltransferase in Mitochondrial and Metabolic FunctionR01DK089312 · NIDDK · DUKE UNIVERSITY · PI DEBORAH M MUOIO · 2010 to 2026
$7.8M
Palmitate Metabolism and Insulin ResistanceR01DK082803 · NIDDK · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI KIEN, CRAIG LAWRENCE · 2010 to 2013
$2.1M
NCRR NIH HHS M01 RR000109NCRR NIH HHS RR00109NIDDK NIH HHS R01 DK082803NIDDK NIH HHS R01DK082803NIDDK NIH HHS R01 DK089312
6 · The paper itself

Abstract

Palmitic acid (PA) is associated with higher blood concentrations of medium-chain acylcarnitines (MCACs), and we hypothesized that PA may inhibit progression of FA β-oxidation. Using a cross-over design, 17 adults were fed high PA (HPA) and low PA/high oleic acid (HOA) diets, each for 3 weeks. The [1-(13)C]PA and [13-(13)C]PA tracers were administered with food in random order with each diet, and we assessed PA oxidation (PA OX) and serum AC concentration to determine whether a higher PA intake promoted incomplete PA OX. Dietary PA was completely oxidized during the HOA diet, but only about 40% was oxidized during the HPA diet. The [13-(13)C]PA/[1-(13)C]PA ratio of PA OX had an approximate value of 1.0 for either diet, but the ratio of the serum concentrations of MCACs to long-chain ACs (LCACs) was significantly higher during the HPA diet. Thus, direct measurement of PA OX did not confirm that the HPA diet caused incomplete PA OX, despite the modest, but statistically significant, increase in the ratio of MCACs to LCACs in blood.

Indexed as

DietAdolescentAdultBody CompositionCarnitineCytokinesDietary FatsFatty AcidsFemaleHumansImmunity, InnateLipid PeroxidationMaleOleic AcidPalmitatesacylcarnitineCarnitineCytokinesDietary FatsFatty AcidsOleic AcidPalmitatescytokinesdehydrogenasesdiet and dietary lipidsfatty acidfatty acid/oxidationincomplete β-oxidation of fatty acidsinflammationinnate immunitylipids/oxidationmacrophages/monocytesmass spectrometrynutritionoleic acidpalmitic acidstable isotopes

Identifiers

PMID26156077
PMCPMC4548784
OpenAlexW2277023352

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.