Evidence map›Paper›PMID 26180108›Full record

Trial reportDiabetes care2015

Randomized Controlled Trial of Intensive Versus Conservative Glucose Control in Patients Undergoing Coronary Artery Bypass Graft Surgery: GLUCO-CABG Trial.

Guillermo Umpierrez, Saumeth Cardona, Francisco Pasquel, Sol Jacobs, Limin Peng, Michael Unigwe, Christopher A Newton, Dawn Smiley-Byrd, Priyathama Vellanki, Michael Halkos and 3 more

2 registry-linked trialsAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 102 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04015752 unknown statusnot on this mapstarted 2019, after this paper: background citation

Sepsis in Intensive Care Unit :Causes and Outcomes of Sepsis in Diabetics Versus Non Diabetics in Assiut University Hospital

TypeobservationalSponsorAssiut UniversityRan2019 to 2020Enrolled100ConditionsSepsis, Septic ShockArmsculture from infected site
NCT04451655 nacompletednot on this mapstarted 2018, after this paper: background citation

Glycemic Stability During the Intraoperative Period Among Patients With DM Undergoing CABG Surgery

TypeinterventionalSponsorAudai A. HayajnehRan2018 to 2018Enrolled72ConditionsBlood GlucoseArmsContinuous insulin infusion
3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. [Hospital diabetes management (Update 2026)].Wiener klinische Wochenschrift · 2026
    Guideline
  2. Pooled it
  3. American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022
    Guideline
  4. Guideline
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
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  15. Trial
  16. Article
  17. Diabetes Management Strategies in Intensive Care Settings.The Medical clinics of North America · 2026
    Review
  18. Review
  19. Review
  20. Article

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Guillermo UmpierrezDepartment of Medicine, Emory University, Atlanta, GA geumpie@emory.edu.
Saumeth CardonaDepartment of Medicine, Emory University, Atlanta, GA.
Francisco PasquelDepartment of Medicine, Emory University, Atlanta, GA.
Sol JacobsDepartment of Medicine, Emory University, Atlanta, GA.
Limin PengRollins School of Public Health, Emory University, Atlanta, GA.
Michael UnigweDepartment of Medicine, Emory University, Atlanta, GA.
Christopher A NewtonDepartment of Medicine, Emory University, Atlanta, GA.
Dawn Smiley-ByrdDepartment of Medicine, Emory University, Atlanta, GA.
Priyathama VellankiDepartment of Medicine, Emory University, Atlanta, GA.
Michael HalkosJoseph B. Whitehead Department of Surgery, Emory University, Atlanta, GA.
John D PuskasJoseph B. Whitehead Department of Surgery, Emory University, Atlanta, GA.
Robert A GuytonJoseph B. Whitehead Department of Surgery, Emory University, Atlanta, GA.
Vinod H ThouraniJoseph B. Whitehead Department of Surgery, Emory University, Atlanta, GA.

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025008 · NCRR · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2007 to 2011
$29.0M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
X LINKED NYSTAGMUS SYNDROME WITH FEATURES OF ALBINISMM01RR000039 · NCRR · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 1985 to 2007
$21.3M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalTL1TR000456 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$1.2M
NCATS NIH HHS TL1 TR000456NCATS NIH HHS UL1 TR000454NCRR NIH HHS M01 RR000039NCRR NIH HHS M01 RR-00039NCRR NIH HHS UL1 RR025008
6 · The paper itself

Abstract

objectiveThe optimal level of glycemic control needed to improve outcomes in cardiac surgery patients remains controversial. RESEARCH DESIGN AND

methodsWe randomized patients with diabetes (n = 152) and without diabetes (n = 150) with hyperglycemia to an intensive glucose target of 100-140 mg/dL (n = 151) or to a conservative target of 141-180 mg/dL (n = 151) after coronary artery bypass surgery (CABG) surgery. After the intensive care unit (ICU), patients received a single treatment regimen in the hospital and 90 days postdischarge. Primary outcome was differences in a composite of complications, including mortality, wound infection, pneumonia, bacteremia, respiratory failure, acute kidney injury, and major cardiovascular events.

resultsMean glucose in the ICU was 132 ± 14 mg/dL (interquartile range [IQR] 124-139) in the intensive and 154 ± 17 mg/dL (IQR 142-164) in the conservative group (P < 0.001). There were no significant differences in the composite of complications between intensive and conservative groups (42 vs. 52%, P = 0.08). We observed heterogeneity in treatment effect according to diabetes status, with no differences in complications among patients with diabetes treated with intensive or conservative regimens (49 vs. 48%, P = 0.87), but a significant lower rate of complications in patients without diabetes treated with intensive compared with conservative treatment regimen (34 vs. 55%, P = 0.008).

conclusionsIntensive insulin therapy to target glucose of 100 and 140 mg/dL in the ICU did not significantly reduce perioperative complications compared with target glucose of 141 and 180 mg/dL after CABG surgery. Subgroup analysis showed a lower number of complications in patients without diabetes, but not in patients with diabetes treated with the intensive regimen. Large prospective randomized studies are needed to confirm these findings.

Indexed as

Coronary Artery BypassAdultAgedAged, 80 and overBlood GlucoseDiabetes MellitusFemaleHumansHyperglycemiaInsulinIntention to Treat AnalysisMaleMiddle AgedProspective StudiesTreatment OutcomeYoung AdultBlood GlucoseInsulin

Identifiers

PMID26180108
PMCPMC4542267

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.