Evidence map›Paper›PMID 26183397›Full record

ArticleOncotarget2015

Knockdown of long non-coding RNA HOTAIR inhibits malignant biological behaviors of human glioma cells via modulation of miR-326.

Jing Ke, Yi-long Yao, Jian Zheng, Ping Wang, Yun-hui Liu, Jun Ma, Zhen Li, Xiao-bai Liu, Zhi-qing Li, Zhen-hua Wang and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 1 synthesis or guideline pooled it, 156 citations in OpenAlex.

  1. Pooled it
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  16. The multifaceted functions of long non-coding RNAExpert reviews in molecular medicine · 2024
    Review
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Jing KeDepartment of Neurobiology, College of Basic Medicine, China Medical University, Shenyang 110122, China.
Yi-long YaoDepartment of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Jian ZhengDepartment of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Ping WangDepartment of Neurobiology, College of Basic Medicine, China Medical University, Shenyang 110122, China.
Yun-hui LiuDepartment of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Jun MaDepartment of Neurobiology, College of Basic Medicine, China Medical University, Shenyang 110122, China.
Zhen LiDepartment of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Xiao-bai LiuDepartment of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Zhi-qing LiDepartment of Neurobiology, College of Basic Medicine, China Medical University, Shenyang 110122, China.
Zhen-hua WangDepartment of Physiology, College of Basic Medicine, China Medical University, Shenyang 110122, China.
Yi-xue XueDepartment of Neurobiology, College of Basic Medicine, China Medical University, Shenyang 110122, China.
China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioma is the most common and aggressive primary adult brain tumor. Long non-coding RNAs (lncRNAs) have important roles in a variety of biological properties of cancers. Here, we elucidated the function and the possible molecular mechanisms of lncRNA HOTAIR in human glioma U87 and U251 cell lines. Quantitative RT-PCR demonstrated that HOTAIR expression was up-regulated in glioma tissues and cell lines. Knockdown of HOTAIR exerted tumor-suppressive function in glioma cells. Further, HOTAIR was confirmed to be the target of miR-326 and miR-326 mediated the tumor-suppressive effects of HOTAIR knockdown on glioma cell lines. Moreover, over-expressed miR-326 reduced the FGF1 expression which played an oncogenic role in glioma by activating PI3K/AKT and MEK 1/2 pathways. In addition, the in vivo studies also supported the above findings. Taken together, knockdown of HOTAIR up-regulated miR-326 expression, and further inducing the decreased expression of FGF1, these results provided a comprehensive analysis of HOTAIR-miR-326-FGF1 axis in human glioma and provided a new potential therapeutic strategy for glioma treatment.

Indexed as

AnimalsBrain NeoplasmsCell Line, TumorFibroblast Growth Factor 1Gene Knockdown TechniquesGenetic TherapyGliomaHumansMiceMice, Inbred BALB CMice, NudeMicroRNAsRNA, Long NoncodingTransfectionUp-RegulationXenograft Model Antitumor AssaysFibroblast Growth Factor 1HOTAIR long untranslated RNA, humanMicroRNAsMIRN326 microRNA, humanRNA, Long NoncodingFGF1gliomaHOTAIRlncRNAmiR-326

Identifiers

PMID26183397
PMCPMC4673137
OpenAlexW2168497087

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.